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    recombinant-rhesus-monkey-folate-binding-proteinfbp-active-ab286067.pdf

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Bioactive grade

Recombinant rhesus monkey Folate Binding Protein/FBP (Active) (ab286067)

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Functional Studies - Recombinant rhesus monkey Folate Binding Protein/FBP (Active) (ab286067)
  • SDS-PAGE - Recombinant rhesus monkey Folate Binding Protein/FBP (Active) (ab286067)

Key features and details

  • Expression system: HEK 293 cells
  • Purity: >= 90% SDS-PAGE
  • Endotoxin level: < 1.000 Eu/µg
  • Active: Yes
  • Tags: His tag C-Terminus
  • Suitable for: SDS-PAGE, Functional Studies

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Protein
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Recombinant cynomolgus monkey Folate Binding Protein/FBP (Active) (ab243048)

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Description

  • Product name

    Recombinant rhesus monkey Folate Binding Protein/FBP (Active)
    See all Folate Binding Protein/FBP proteins and peptides
  • Biological activity

    Immobilized Folic acid-BSA conjugate at 20 µg/mL (100 µL/well) can bind Rhesus macaque FOLR1, with a linear range of 0.156-2.5 µg/mL

  • Purity

    >= 90 % SDS-PAGE.

  • Endotoxin level

    < 1.000 Eu/µg
  • Expression system

    HEK 293 cells
  • Accession

    F7BP60
  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Rhesus monkey
    • Predicted molecular weight

      26 kDa including tags
    • Actual molecular weight

      35 kDa including tags
    • Molecular weight information

      The protein has a calculated MW of 26.4 kDa. The protein migrates as 35-41 kDa under reducing conditions (SDS-PAGE) due to glycosylation.
    • Amino acids

      25 to 233
    • Tags

      His tag C-Terminus

Specifications

Our Abpromise guarantee covers the use of ab286067 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • Form

    Lyophilized
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

    pH: 7.40
    Constituent: PBS

    Normally Mannitol or Trehalose is added as protectants before lyophilization.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Reconstitute in sterile deionized water to a concentration of 50 µg/ml. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% (W/V) HSA or BSA) is recommended for further dilution and long term storage. Do not vortex. After reconstitution, aliquot and store at -80°C and use within 3 months.

General Info

  • Alternative names

    • adult
    • Adult folate binding protein
    • Adult folate-binding protein
    • FBP
    • Folate Binding Protein
    • Folate receptor
    • Folate receptor 1
    • Folate Receptor 1 Adult
    • Folate Receptor 1 Precursor
    • Folate receptor adult
    • Folate receptor alpha
    • FOLR
    • FOLR1
    • FOLR1_HUMAN
    • FR alpha
    • FR-alpha
    • FRalpha
    • KB cells FBP
    • MOV18
    • Ovarian cancer associated antigen
    • Ovarian tumor associated antigen
    • Ovarian tumor associated antigen MOv18
    • Ovarian tumor-associated antigen MOv18
    see all
  • Function

    Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
  • Tissue specificity

    Exclusively expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum.
  • Involvement in disease

    Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]. NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Note=Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function.
  • Sequence similarities

    Belongs to the folate receptor family.
  • Post-translational
    modifications

    Eight disulfide bonds are present.
    The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
  • Cellular localization

    Cell membrane. Secreted.
  • Target information above from: UniProt accession P15328 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Images

  • Functional Studies - Recombinant rhesus monkey Folate Binding Protein/FBP (Active) (ab286067)
    Functional Studies - Recombinant rhesus monkey Folate Binding Protein/FBP (Active) (ab286067)

    Immobilized Folic acid-BSA conjugate at 20 μg/mL (100 μL/well) can bind Rhesus macaque FOLR1, with a linear range of 0.156-2.5 μg/mL

  • SDS-PAGE - Recombinant rhesus monkey Folate Binding Protein/FBP (Active) (ab286067)
    SDS-PAGE - Recombinant rhesus monkey Folate Binding Protein/FBP (Active) (ab286067)

    SDS-PAGE analysis of ab286067 under reducing conditions (R).

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • Datasheet download

    Download

References (0)

Publishing research using ab286067? Please let us know so that we can cite the reference in this datasheet.

ab286067 has not yet been referenced specifically in any publications.

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