Description

  • Product name

    Recombinant Rubella virus E1 protein
    See all Rubella virus E1 proteins and peptides
  • Purity

    > 80 % SDS-PAGE.
    ab107947 is purified by Metal affinity chromatography.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant

    Specifications

    Our Abpromise guarantee covers the use of ab107947 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Western blot

      ELISA

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

      Preservative: 0.1% Sodium azide
      Constituent: 0.0036% Hydrochloric acid

    General Info

    • Alternative names

      • E1
      • E1 envelope glycoprotein
      • Glycoprotein E1
      • Spike glycoprotein E1
    • Relevance

      Rubella virus is the only member of the Rubrivirus genus of the Togavirus family. Unlike most Togaviruses it is NOT arthropod borne, but is acquired via the respiratory route. It is an enveloped (toga=cloak), non-segmented, positive sense, RNA virus and replicates in the cytoplasm. It consists of 3 structural proteins; E1,E2 membrane bound glycoproteins, and C capsid protein. E1 envelope glycoprotein is a class II viral fusion protein. Fusion activity is inactive as long as E1 is bound to E2 in mature virion. After virus attachment to target cell and endocytosis, acidification of the endosome induces dissociation of E1/E2 heterodimer and trimerization of the E1 subunits. This E1 homotrimer is fusion active, and promotes release of viral nucleocapsid in the cytoplasm after cell and viral membrane fusion. The E1 cytoplasmic tail modulates virus release, and the tyrosines residues are critical for this function.

    References

    ab107947 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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