Product nameRecombinant SARS E protein
Biological activityImmunoreactive with sera from SARS-infected individuals.
Purity> 95 % SDS-PAGE.
Expression systemEscherichia coli
Protein lengthProtein fragment
Our Abpromise guarantee covers the use of ab48949 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Constituents: 48% Urea, 0.2% SDS, 0.58% Sodium chloride
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- E protein
- Envelope protein
- Envelope small membrane protein
RelevanceA novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive stranded RNA approximately 27 to 31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2. The evelope protein is a component of the viral envelope that plays a central role in virus morphogenesis and assembly. It may be sufficient to form virus like particles.
Cellular localizationCell Membrane; single pass membrane protein.
ab48949 has not yet been referenced specifically in any publications.