Description

  • Product name

    Recombinant Scorpion Agitoxin2 protein
  • Expression system

    Escherichia coli
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Scorpion

Specifications

Our Abpromise guarantee covers the use of ab57372 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

    pH: 7.50
    Constituents: 0.121% Tris, 0.0292% EDTA, 0.58% Sodium chloride, 0.1% BSA

  • Reconstitution
    Reconstitute with 10 mM Tris, pH 7.5, containing 100 mM sodium chloride, 0.1% bovine serum albumin and 1 mM EDTA.

General Info

  • Alternative names

    • Agitoxin 2
    • AgTx 2
    • AgTx2
    • Potassium channel toxin alpha KTx 3.2
  • Relevance

    Agitoxin is a toxin found in the venom of the scorpion Leiurus quinquestriatus herbraeus (yellow scorpion). Agitoxin binds to the Shaker K+ channel in Drosophila as well as to its mammalian homologue. It blocks this channel by binding with high affinity (Kd < 1 nM) to its external vestibule. Its structure consists of a triple-stranded antiparallel beta-sheet and a single helix covering one face of the beta-sheet. The cysteine side chains connect the beta-sheet and the helix form to the core of the molecule. The fold of agitoxin is homologous to the previously determined folds of scorpion venom toxins. Three types of agitoxin can be distinguished; all 3 agitoxins have been identified as 38 amino acid toxins (cystine bonds not shown): Agitoxin-2 Gly-Val-Pro-Ile-Asn-Val-Ser-Cys-Thr-Gly-Ser-Pro-Gln-Cys-Ile-Lys-Pro-Cys-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys-Met-Asn-Arg-Lys-Cys-His-Cys-Thr-Pro-Lys Molecular Formula = 169H278N54O48S8
  • Cellular localization

    Secreted

References

ab57372 has not yet been referenced specifically in any publications.

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