Anti-RECQL4 antibody (ab192375)
Key features and details
- Rabbit polyclonal to RECQL4
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Overview
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Product name
Anti-RECQL4 antibody
See all RECQL4 primary antibodies -
Description
Rabbit polyclonal to RECQL4 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
Synthetic peptide corresponding to Human RECQL4.
Database link: O94761 -
Positive control
- HeLa and NIH-3T3 whole cell lysates. Rat brain tissue lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituents: 50% Glycerol, 49% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
Purity is > 95% (by SDS-PAGE). -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab192375 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use at an assay dependent concentration. Predicted molecular weight: 133 kDa.
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Notes |
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WB
Use at an assay dependent concentration. Predicted molecular weight: 133 kDa. |
Target
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Function
DNA-dependent ATPase. May modulate chromosome segregation. -
Tissue specificity
Ubiquitously expressed, with highest levels in thymus and testis. -
Involvement in disease
Defects in RECQL4 are a cause of Rothmund-Thomson syndrome (RTS) [MIM:268400]. A disease characterized by dermatological features such as atrophy, pigmentation, and telangiectasia and frequently accompanied by juvenile cataract, saddle nose, congenital bone defects, disturbances of hair growth, and hypogonadism.
Defects in RECQL4 are a cause of RAPADILINO syndrome (RAPADILINOS) [MIM:266280]. A disease characterized by radial and patellar aplasia or hypoplasia.
Defects in RECQL4 are a cause of Baller-Gerold syndrome (BGS) [MIM:218600]; also known as craniosynostosis with radial defects. BGS is an autosomal recessive syndrome characterized by short stature, craniosynostosis, absent or hypoplastic radii, short and curved ulna, fused carpal bones and absent carpals, metacarpals and phalanges. Some patients manifest poikiloderma. Cases reported as Baller-Gerold syndrome have phenotypic overlap with several other disorders, including Saethre-Chotzen syndrome. BGS is part of the clinical spectrum of Rothmund-Thomson and RAPADILINO syndromes. -
Sequence similarities
Belongs to the helicase family. RecQ subfamily.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain. -
Cellular localization
Cytoplasm. Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 9401 Human
- Entrez Gene: 79456 Mouse
- Entrez Gene: 300057 Rat
- Omim: 603780 Human
- SwissProt: O94761 Human
- SwissProt: Q75NR7 Mouse
- Unigene: 31442 Human
- Unigene: 18373 Mouse
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Alternative names
- ATP dependent DNA helicase Q4 antibody
- ATP-dependent DNA helicase Q4 antibody
- DNA helicase antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab192375 has not yet been referenced specifically in any publications.