Overview

  • Product name

  • Description

    Rabbit polyclonal to RECQL4
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human RECQL4.
    Database link: O94761

  • Positive control

    • HeLa and NIH-3T3 whole cell lysates. Rat brain tissue lysate.
  • General notes

    Previously labelled as RECQ4. 

Properties

Applications

Our Abpromise guarantee covers the use of ab192375 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 133 kDa.

Target

  • Function

    DNA-dependent ATPase. May modulate chromosome segregation.
  • Tissue specificity

    Ubiquitously expressed, with highest levels in thymus and testis.
  • Involvement in disease

    Defects in RECQL4 are a cause of Rothmund-Thomson syndrome (RTS) [MIM:268400]. A disease characterized by dermatological features such as atrophy, pigmentation, and telangiectasia and frequently accompanied by juvenile cataract, saddle nose, congenital bone defects, disturbances of hair growth, and hypogonadism.
    Defects in RECQL4 are a cause of RAPADILINO syndrome (RAPADILINOS) [MIM:266280]. A disease characterized by radial and patellar aplasia or hypoplasia.
    Defects in RECQL4 are a cause of Baller-Gerold syndrome (BGS) [MIM:218600]; also known as craniosynostosis with radial defects. BGS is an autosomal recessive syndrome characterized by short stature, craniosynostosis, absent or hypoplastic radii, short and curved ulna, fused carpal bones and absent carpals, metacarpals and phalanges. Some patients manifest poikiloderma. Cases reported as Baller-Gerold syndrome have phenotypic overlap with several other disorders, including Saethre-Chotzen syndrome. BGS is part of the clinical spectrum of Rothmund-Thomson and RAPADILINO syndromes.
  • Sequence similarities

    Belongs to the helicase family. RecQ subfamily.
    Contains 1 helicase ATP-binding domain.
    Contains 1 helicase C-terminal domain.
  • Cellular localization

    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • ATP dependent DNA helicase Q4 antibody
    • ATP-dependent DNA helicase Q4 antibody
    • DNA helicase antibody
    • DNA helicase, RecQ like type 4 antibody
    • RECQ 4 antibody
    • RECQ L4 antibody
    • RecQ protein 4 antibody
    • RecQ protein like 4 antibody
    • RecQ protein-like 4 antibody
    • RecQ-like type 4 antibody
    • RecQ4 antibody
    • RECQ4_HUMAN antibody
    • RECQL 4 antibody
    • RECQL4 antibody
    • RTS antibody
    see all

Images

  • All lanes : Anti-RECQL4 antibody (ab192375) at 1/500 dilution

    Lane 1 : HeLa whole cell lysates.
    Lane 2 : NIH-3T3 whole cell lysates.
    Lane 3 : Rat brain tissue lysates.

    Predicted band size: 133 kDa

References

ab192375 has not yet been referenced specifically in any publications.

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