Overview

  • Product name

    Anti-Red Blood Cells antibody [34-3C]
    See all Red Blood Cells primary antibodies
  • Description

    Mouse monoclonal [34-3C] to Red Blood Cells
  • Host species

    Mouse
  • Specificity

    Recognizes an exposed surface determinant of intact Red Blood Cells. ab106101 only recognises antigenic determinants expressed on Mouse RBC and not on other species of RBC.
  • Tested applications

    Suitable for: Functional Studies, Flow Cytmore details
  • Species reactivity

    Reacts with: Mouse
    Does not react with: Rat, Sheep, Rabbit, Chicken, Human
  • Immunogen

    Mouse Red Blood Cells

  • Positive control

    • Mouse erythrocytes
  • General notes


    This antibody efficiently binds to Fc receptors on macrophages inducing anemia in vivo due to a rapid Fc receptor (FcyR)-mediated erythrophagocytosis of opsonised RBC in spleen and livers. The capacity of the antibody to interact with FcyR is responsible for its haemolytic activity.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    Constituents: 0.1% BSA, PBS
  • Concentration information loading...
  • Purity

    Protein G purified
  • Purification notes

    0.2 µm filtered solution
  • Primary antibody notes

    This antibody efficiently binds to Fc receptors on macrophages inducing anemia in vivo due to a rapid Fc receptor (FcyR)-mediated erythrophagocytosis of opsonised RBC in spleen and livers. The capacity of the antibody to interact with FcyR is responsible for its haemolytic activity.
  • Clonality

    Monoclonal
  • Clone number

    34-3C
  • Isotype

    IgG2a
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab106101 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies Use at an assay dependent concentration.
Flow Cyt 1/50.

ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

 

Target

  • Relevance

    Red blood cells are the most common type of blood cell and are the vertebrate body's principal means of delivering oxygen from the lungs or gills to body tissues via the blood.
  • Alternative names

    • Erythrocytes antibody
    • RBCs antibody

References

This product has been referenced in:

  • Baudino L  et al. Differential contribution of three activating IgG Fc receptors (FcgammaRI, FcgammaRIII, and FcgammaRIV) to IgG2a- and IgG2b-induced autoimmune hemolytic anemia in mice. J Immunol 180:1948-53 (2008). Read more (PubMed: 18209093) »
  • Azeredo da Silveira S  et al. Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody. J Exp Med 195:665-72 (2002). Read more (PubMed: 11901193) »
See all 3 Publications for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab106101.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up