Key features and details
- Rabbit polyclonal to Reg3a
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Reg3a antibody
See all Reg3a primary antibodies
DescriptionRabbit polyclonal to Reg3a
SpecificityThis antibody detects endogenous levels of total Reg3a protein.
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Synthetic peptide corresponding to Human Reg3a (internal sequence).
Database link: Q06141
- Human gastric cancer and human brain tissue.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab198824 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/25 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
FunctionBactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.
Tissue specificityHighly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis.
Sequence similaritiesContains 1 C-type lectin domain.
DomainThe EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity.
modificationsProteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.
Cellular localizationSecreted. Found in the apical region of pancreatic acinar cells.
- Information by UniProt
- FLJ18565 antibody
- Hepatocarcinoma intestine pancreas antibody
- Hepatointestinal pancreatic protein antibody
ab198824 has not yet been referenced specifically in any publications.