Overview

  • Product name

  • Description

    Rabbit polyclonal to Reg3a
  • Host species

    Rabbit
  • Specificity

    This antibody detects endogenous levels of total Reg3a protein.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human Reg3a (internal sequence).
    Database link: Q06141

  • Positive control

    • Human gastric cancer and human brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab198824 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/25 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.
  • Tissue specificity

    Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis.
  • Sequence similarities

    Contains 1 C-type lectin domain.
  • Domain

    The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity.
  • Post-translational
    modifications

    Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.
  • Cellular localization

    Secreted. Found in the apical region of pancreatic acinar cells.
  • Information by UniProt
  • Database links

  • Alternative names

    • FLJ18565 antibody
    • Hepatocarcinoma intestine pancreas antibody
    • Hepatointestinal pancreatic protein antibody
    • HIP antibody
    • HIP/PAP antibody
    • Human proislet peptide antibody
    • INGAP antibody
    • Pancreatic beta cell growth factor antibody
    • Pancreatitis associated protein 1 antibody
    • Pancreatitis associated protein antibody
    • Pancreatitis-associated protein 1 antibody
    • PAP antibody
    • PAP H antibody
    • PAP homologous protein antibody
    • PAP1 antibody
    • PBCGF antibody
    • Proliferation inducing protein 34 antibody
    • Proliferation inducing protein 42 antibody
    • Reg III alpha antibody
    • REG III antibody
    • Reg III-alpha antibody
    • REG-3-alpha antibody
    • REG3 antibody
    • Reg3a antibody
    • REG3A_HUMAN antibody
    • Regenerating islet derived 3 alpha antibody
    • Regenerating islet derived protein 3 alpha precursor antibody
    • Regenerating islet-derived protein 3-alpha 15 kDa form antibody
    • Regenerating islet-derived protein III-alpha antibody
    see all

Images

  • Immunohistochemical staining of paraffin-embedded human brain tissue labeling Reg3a using ab198824 at a 1/20 dilution.

  • Immunohistochemical staining of paraffin-embedded human gastric cancer tissue labeling Reg3a using ab198824 at a 1/20 dilution.

References

ab198824 has not yet been referenced specifically in any publications.

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