Regorafenib, multikinase inhibitor (ab216314)

Overview

  • Product name

    Regorafenib, multikinase inhibitor
  • Description

    Potent multikinase inhibitor
  • Alternative names

    • BAY 73-4506
    • Fluoro-Sorafenib
    • Stivarga
  • Biological description

    Potent multikinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, RET and Raf-1 (IC50 values are 13, 4.2, 46, 22, 7, 1.5 and 2.5nM, respectively). Orally bioavailable antitumor, antiangiogenic, antiproliferative and antineoplastic agent.


     

  • CAS Number

    755037-03-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea

  • Molecular weight

    482.82
  • Molecular formula

    C21H15ClF4N4O3
  • Storage instructions

    Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO (>50mg/ml). Slightly soluble in ethanol (1mg/ml). Insoluble in water.

  • SMILES

    O=C(NC)c3cc(Oc2ccc(NC(=O)Nc1cc(c(Cl)cc1)C(F)(F)F)c(F)c2)ccn3

References

This product has been referenced in:

  • Zopf D  et al. Pharmacologic activity and pharmacokinetics of metabolites of regorafenib in preclinical models. Cancer Med N/A:N/A (2016). Read more (PubMed: 27734608) »
  • Chen D  et al. Regorafenib inhibits colorectal tumor growth through PUMA-mediated apoptosis. Clin Cancer Res 20:3472-84 (2014). Read more (PubMed: 24763611) »
  • Schmieder R  et al. Regorafenib (BAY 73-4506): antitumor and antimetastatic activities in preclinical models of colorectal cancer. Int J Cancer 135:1487-96 (2014). Read more (PubMed: 24347491) »
  • Wilhelm SM  et al. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer 129:245-55 (2011). Read more (PubMed: 21170960) »

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