Key features and details
- Rabbit polyclonal to Rel B
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-Rel B antibody
See all Rel B primary antibodies
DescriptionRabbit polyclonal to Rel B
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Rat, Human
- HuT78, L929, C6 or NIH3T3 nuclear lysate
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Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Storage bufferPreservative: 0.03% Sodium azide
Constituents: 0.01% BSA, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, HEPES
Concentration information loading...
Our Abpromise guarantee covers the use of ab71543 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/2000. Detects a band of approximately 62 kDa (predicted molecular weight: 62 kDa).|
FunctionNF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49.
Sequence similaritiesContains 1 RHD (Rel-like) domain.
DomainBoth N- and C-terminal domains are required for transcriptional activation.
modificationsPhosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation.
Cellular localizationNucleus. Cytoplasm > cytoskeleton > centrosome. Co-localizes with NEK6 in the centrosome.
- Information by UniProt
- I REL antibody
- I-Rel antibody
- IREL antibody
ab71543 has not yet been referenced specifically in any publications.