Overview

  • Product name

    Anti-Renalase antibody [RNLS/1940]
    See all Renalase primary antibodies
  • Description

    Mouse monoclonal [RNLS/1940] to Renalase
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human Renalase aa 34-235. The exact sequence is proprietary.
    Database link: Q5VYX0

  • Positive control

    • IHC-P: Human kidney tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab236560 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 1 - 2 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Incubate with primary antibody for 30 minutes at RT.

Target

  • Function

    Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis (By similarity). According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity.
  • Tissue specificity

    Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects.
  • Sequence similarities

    Belongs to the renalase family.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • 6530404N21Rik antibody
    • AI452315 antibody
    • AW060440 antibody
    • C10orf59 antibody
    • Chromosome 10 open reading frame 59 antibody
    • FLJ11218 antibody
    • HGNC:25641 antibody
    • Hypothetical protein LOC55328 antibody
    • MAO C antibody
    • MAO-C antibody
    • mMAO C antibody
    • Monoamine oxidase C antibody
    • Monoamine oxidase-C antibody
    • Renalase antibody
    • Renalase FAD dependent amine oxidase antibody
    • RNLS antibody
    • RNLS_HUMAN antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded human kidney tissue stained for Renalase using ab236560 at 2 µg/ml in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human kidney tissue stained for Renalase using ab236560 at 2 µg/ml in immunohistochemical analysis.

References

ab236560 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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