Anti-Renin Receptor antibody (ab151241)
- Datasheet
- References
- Protocols
Overview
-
Product name
Anti-Renin Receptor antibody
See all Renin Receptor primary antibodies -
Description
Rabbit polyclonal to Renin Receptor -
Host species
Rabbit -
Tested applications
Suitable for: WB, ICC/IFmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Cow
-
Immunogen
Recombinant fragment corresponding to Human Renin Receptor aa 146-350.
-
Positive control
- 293T, A431, H1299, HeLa, HepG2, Molt-4 and Raji cell lysates; HepG2 cells.
-
General notes
Protein target previously labeled as POU3F2.
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.00
Preservative: 0.025% Proclin
Constituents: PBS, 20% Glycerol -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
-
Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab151241 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | 1/500 - 1/3000. Predicted molecular weight: 39 kDa. | |
| ICC/IF | 1/100 - 1/1000. |
Target
-
Function
Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS). -
Tissue specificity
Expressed in brain, heart, placenta, liver, kidney and pancreas. Barely detectable in lung and skeletal muscles. In the kidney cortex it is restricted to the mesangium of glomeruli. In the coronary and kidney artery it is expressed in the subendothelium, associated to smooth muscles where it colocalizes with REN. Expressed in vascular structures and by syncytiotrophoblast cells in the mature fetal placenta. -
Involvement in disease
Defects in ATP6AP2 are a cause of mental retardation X-linked with epilepsy (MRXE) [MIM:300423]. MRXE is a syndromic mental retardation. Patients manifest mild to moderate mental retardation associated with epilepsy, delays in motor milestones and speech acquisition in infancy. -
Post-translational
modificationsPhosphorylated. -
Cellular localization
Membrane. - Information by UniProt
-
Database links
- Entrez Gene: 513520 Cow
- Entrez Gene: 10159 Human
- Entrez Gene: 70495 Mouse
- Entrez Gene: 302526 Rat
- Omim: 300556 Human
- SwissProt: P81134 Cow
- SwissProt: O75787 Human
- SwissProt: Q9CYN9 Mouse
see all -
Alternative names
- APT6M8 9 antibody
- APT6M8-9 antibody
- ATP6AP2 antibody
see all
Images
-
Western blot - Anti-Renin Receptor antibody (ab151241)Anti-Renin Receptor antibody (ab151241) at 1/1000 dilution + HeLa whole cell lysate at 30 µg
Predicted band size: 39 kDa
10% SDS PAGE -
Immunocytochemistry/ Immunofluorescence - Anti-Renin Receptor antibody (ab151241)Immunofluorescence analysis of methanol-fixed HepG2 cells labeling Renin Receptor with ab151241 at 1/200 dilution. The image in the lower panel is costained with Hoechst 33342.
References
ab151241 has not yet been referenced specifically in any publications.
