Repaglinide, SUR1/Kir6.2 potassium channel blocker (ab143000)

Overview

  • Product name

    Repaglinide, SUR1/Kir6.2 potassium channel blocker
  • Description

    Potent SUR1/Kir6.2 potassium channel blocker
  • Purity

    > 99%
  • CAS Number

    135062-02-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Ethoxy-4-[2-[[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino]-2-oxoethyl]benzoic acid
  • Molecular weight

    452.59
  • Molecular formula

    C27H36N2O4
  • PubChem identifier

    65981
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1(=C(C=CC(=C1)CC(N[C@H](C2=CC=CC=C2N3CCCCC3)CC(C)C)=O)C(O)=O)OCC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Sim YB  et al. Repaglinide, but not nateglinide administered supraspinally and spinally exerts an anti-diabetic action in d-glucose fed and streptozotocin-treated mouse models. Korean J Physiol Pharmacol 17:493-7 (2013). Read more (PubMed: 24381497) »
  • Kühner P  et al. Importance of the Kir6.2 N-terminus for the interaction of glibenclamide and repaglinide with the pancreatic K(ATP) channel. Naunyn Schmiedebergs Arch Pharmacol 385:299-311 (2012). Read more (PubMed: 22083559) »
  • Yang TT  et al. Opening of ATP-sensitive potassium channel by insulin in the brain-induced insulin secretion in Wistar rats. Horm Metab Res 42:110-4 (2010). Read more (PubMed: 19890806) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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