Key features and details
- Rabbit polyclonal to Repulsive Guidance Molecule A
- Suitable for: ICC/IF
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Repulsive Guidance Molecule A antibody
See all Repulsive Guidance Molecule A primary antibodies
DescriptionRabbit polyclonal to Repulsive Guidance Molecule A
Tested applicationsSuitable for: ICC/IFmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Chicken, Cynomolgus monkey
- ICC/IF: RH-30 cells.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab220253 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use a concentration of 0.25 - 2 µg/ml.|
FunctionMember of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS1-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
Sequence similaritiesBelongs to the repulsive guidance molecule (RGM) family.
Cellular localizationCell membrane.
- Information by UniProt
- Repulsive guidance molecule A antibody
- RGM antibody
- RGM domain family member A antibody
ab220253 has not yet been referenced specifically in any publications.