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High-quality reagents for autoimmune disease R&D

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  • Immunology and infectious diseases
    • All immunology resources
      • Customized proteomic reagents
        • Cytokine network interactive poster
          • Improving efficiency in drug discovery

            Access the research tools you need to better understand autoimmune diseases and partner with us to develop new reagents and antibody panels for emerging targets.

            Browse all autoimmune disease products

            Published February 22, 2022

            Contents

            • Key strengths of our autoimmune disease portfolio
            • Our end-to-end solutions for autoimmune disease research
            • Solutions for biomarker research: from ELISA kits to multiplex immunoassays


            With the incidence of autoimmune diseases rising worldwide, research into translational immunology is becoming increasingly important, strengthening the demand for high-quality, specific biological reagents for research, drug discovery and diagnostics development.

            Whether you’re trying to understand disease mechanisms, discover novel treatment strategies, or develop validated strategies for patient stratification for biologics treatments, we can support you with a broad, comprehensively validated portfolio covering key and emerging targets in autoimmune diseases.

            Key strengths of our autoimmune disease portfolio

            Our autoimmune disease portfolio is aligned with three key therapeutic areas: rheumatology (eg, rheumatoid arthritis and lupus), gastroenterology (eg, inflammatory bowel disease), and dermatology (eg, psoriasis).

            Key benefits of our autoimmune disease portfolio:

            • Our established and continually expanding portfolio of recombinant monoclonal antibodies is one of the largest on the market and includes a wide selection of niche targets.
            • Comprehensively validated antibodies with strong and specific signals for extra & intra-cellular flow cytometry, IHC, ICC and WB and detailed information on the validation process
            • Sensitive and specific immunoassays for key cytokines and chemokines to investigate key biomarkers for autoimmune diseases
            • Our large selection of directly conjugated primary antibodies, carrier-free recombinant antibodies and conjugation kits offers you unrivaled flexibility for flow cytometry and imaging applications.
            • All recombinant antibodies and matched antibody pairs in our immunology range are available as carrier-free formulations for easy antibody labeling and sandwich immunoassay development. 

            To ensure we continually develop our portfolio to meet the evolving needs of our customers, we work with an expert network of key opinion leaders who help us identify novel targets and emerging technologies to expand our range of high-quality reagents.

            If a research tool you need is not available off the shelf, our in-house team of experts will work with you to create a customized solution.

            Our end-to-end solutions for autoimmune disease research

            We’re committed to covering all widely studied and emerging targets for autoimmune diseases, including:

            • Key immunology targets for therapeutics development:
              • Cytokines: IL-2, IL-6, TNF, IFN, IL-10, IL-23
              • Chemokines (including receptors): CX3CL1, CXCR5
              • Kinases: JAK1, JAK2, JAK3, BTK, TYK2, Tec, Syk, S1P/R
              • Integrins/adhesion molecules: Integrin beta 7, Integrin alpha 4, MAdCAM1, Integrin alpha 9
              • B and T cell associated targets (including common immune checkpoints): CD40, PDL1, CD19
              • Transcription factors/regulators: STAT3, RoRyT, AhR
              • Complement system targets: c1q, c3, c5            
            • Emerging targets for autoimmune diseases:
              • T-reg enhancing, eg TNFR2
              • Galectins, eg Galectin 1 and Galectin 3
              • Innate immunity targets, eg caspase 4/ caspase 5, NLRP3, pentraxin 3
            • Newly described targets with potential therapeutic relevance

            Take advantage of our wide range of well-validated proteomic reagents for autoimmune disease research—from recombinant antibodies and ELISA kits to proteins and edited cell lines — with excellent batch-to-batch consistency and guaranteed long-term supply.

            Browse all autoimmune disease products


            Product category

            ​

            Recombinant antibodies

            Carrier-free and primary antibody conjugates

            Human recombinant bioactive proteins

            Research goal

            Investigate novel mechanistic and treatment targets in autoimmune diseases

            More flexibility to characterize new cell populations via flow cytometry

            Stimulate immune cells with bioactive cytokines and chemokines

            Benefits

            Guaranteed long-term supply, confirmed specificity, and the highest level of consistency between batches. 

            Wide label coverage across the imaging spectrum to enable flexibility in panel building

            Batch-to-batch consistent bioactive proteins suitable for functional studies and cell culture; a broad range of antigens for immunoassay development

            Recommended products for IBD research

            S100A9 (ab92507)

            MMP3 (ab52915)

            Integrin beta 4 (ab182120)

            PE Anti-IL-33 (ab282176)

            APC Anti-GATA3 (ab225418)

            IL-1 beta (ab259387)

            IL-6 (ab259381)
            Recommended products for rheumatology research

            JAK2 (ab108596)

            MMP1 (ab52631)

            Interferon alpha/beta receptor 1 (ab124764)

            MIF carrier-free (ab226166)

            CD74 carrier-free (ab289891)

            OSM (ab270077)

            TNF alpha (ab259410)
            Recommended products for dermatology research

            C3 (ab200999)

            Adiponectin (ab181281)

            JAK3 (ab45141)

            Alexa Fluor® 647 aryl hydrocarbon receptor (ab225358)

            IL-23R carrier-free (ab255964)

            IL-17A (ab282392)

            GM-CSF (ab259376)

            Solutions for biomarker research: from ELISA kits to multiplex immunoassays

            Autoimmune disease biomarkers are important for research, can serve as a diagnostic and are used to monitor the progress of drug therapy. See below our comprehensive portfolio of ELISA kits, antibody pairs, and FirePlex multiplex immunoassays for human samples to accelerate biomarker research in autoimmune diseases.  


            Product category

            Human SimpleStep ELISA® kits

            Human ELISA antibody pairs

            FirePlex® multiplex immunoassays

            Research goals

            Rapidly validate autoimmune disease biomarkers to stratify patients by disease severity

            Develop your own ELISA assay

            Simultaneously profile key inflammation markers

            Benefit

            With just one wash step and no compromise in performance, our highly sensitive ELISA kits give you reliable results in 90 minutes. 

            High-performing matched antibody pairs allow you to achieve consistent, specific and sensitive results, while carrier-free formulations give you more flexibility in terms of conjugation and assay setup.

            High-throughput no-wash automation-friendly immunoassays, ideal for discovery, screening, and profiling projects.

            Common autoimmune markers

            IL-6 (ab178013)

            IFN gamma (ab174443)

            MCP1 (ab241803)


            CRP (ab270347)

            FirePlex®-384 Cytokines, Human

            Immunoassay Panel 1 (ab234897): IL-8, IFN gamma, IL-4, IL-1 beta, MCP1, TNF alpha, IL-10, IL-17A, IL-2, IL-6


            FirePlex®-96 Inflammation, Human Immunoassay Panel (ab243550): IFN gamma, IL-1 beta, IL-6, IL-8, IL-10, IL-12p70, MCP1, TNF alpha


            FirePlex®-384 TGF-beta (Human, Mouse, Rat, NHP) Immunoassay Panel (ab270739) -TGF-B1, TGF-B2, and TGF-B3

            IBD markers

            OSM (ab215543)

            IL23 (ab221837)

            TNF (ab181421)

            IL-8 (ab241839)

            MMP9 (ab241787)

            IL-1 beta (ab241807)

            RA markers

            Leptin (ab179884)

            Resistin (ab183364)

            YWHAH (ab253731)

            Vimentin (ab256671)

            Lupus markers

            IP-10 (ab173194)

            CXCL16 (ab183366)

            BCMA (ab267696)

            NFSF12 (ab253680)

            Psoriasis markers

            Albumin (ab227933)

            Factor VII (ab190810)

            IL-17A (ab241882)

            Annexin A2 (ab267720)









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