High-quality reagents for autoimmune disease R&D
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Access the research tools you need to better understand autoimmune diseases and partner with us to develop new reagents and antibody panels for emerging targets.
With the incidence of autoimmune diseases rising worldwide, research into translational immunology is becoming increasingly important, strengthening the demand for high-quality, specific biological reagents for research, drug discovery and diagnostics development.
Whether you’re trying to understand disease mechanisms, discover novel treatment strategies, or develop validated strategies for patient stratification for biologics treatments, we can support you with a broad, comprehensively validated portfolio covering key and emerging targets in autoimmune diseases.
Key strengths of our autoimmune disease portfolio
Our autoimmune disease portfolio is aligned with three key therapeutic areas: rheumatology (eg, rheumatoid arthritis and lupus), gastroenterology (eg, inflammatory bowel disease), and dermatology (eg, psoriasis).
Key benefits of our autoimmune disease portfolio:
- Our established and continually expanding portfolio of recombinant monoclonal antibodies is one of the largest on the market and includes a wide selection of niche targets.
- Comprehensively validated antibodies with strong and specific signals for extra & intra-cellular flow cytometry, IHC, ICC and WB and detailed information on the validation process
- Sensitive and specific immunoassays for key cytokines and chemokines to investigate key biomarkers for autoimmune diseases
- Our large selection of directly conjugated primary antibodies, carrier-free recombinant antibodies and conjugation kits offers you unrivaled flexibility for flow cytometry and imaging applications.
- All recombinant antibodies and matched antibody pairs in our immunology range are available as carrier-free formulations for easy antibody labeling and sandwich immunoassay development.
To ensure we continually develop our portfolio to meet the evolving needs of our customers, we work with an expert network of key opinion leaders who help us identify novel targets and emerging technologies to expand our range of high-quality reagents.
If a research tool you need is not available off the shelf, our in-house team of experts will work with you to create a customized solution.
Our end-to-end solutions for autoimmune disease research
We’re committed to covering all widely studied and emerging targets for autoimmune diseases, including:
- Key immunology targets for therapeutics development:
- Cytokines: IL-2, IL-6, TNF, IFN, IL-10, IL-23
- Chemokines (including receptors): CX3CL1, CXCR5
- Kinases: JAK1, JAK2, JAK3, BTK, TYK2, Tec, Syk, S1P/R
- Integrins/adhesion molecules: Integrin beta 7, Integrin alpha 4, MAdCAM1, Integrin alpha 9
- B and T cell associated targets (including common immune checkpoints): CD40, PDL1, CD19
- Transcription factors/regulators: STAT3, RoRyT, AhR
- Complement system targets: c1q, c3, c5
- Emerging targets for autoimmune diseases:
- T-reg enhancing, eg TNFR2
- Galectins, eg Galectin 1 and Galectin 3
- Innate immunity targets, eg caspase 4/ caspase 5, NLRP3, pentraxin 3
- Newly described targets with potential therapeutic relevance
Take advantage of our wide range of well-validated proteomic reagents for autoimmune disease research—from recombinant antibodies and ELISA kits to proteins and edited cell lines — with excellent batch-to-batch consistency and guaranteed long-term supply.
Product category |
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Research goal | Investigate novel mechanistic and treatment targets in autoimmune diseases | More flexibility to characterize new cell populations via flow cytometry | Stimulate immune cells with bioactive cytokines and chemokines |
Benefits | Guaranteed long-term supply, confirmed specificity, and the highest level of consistency between batches. | Wide label coverage across the imaging spectrum to enable flexibility in panel building | Batch-to-batch consistent bioactive proteins suitable for functional studies and cell culture; a broad range of antigens for immunoassay development |
| Recommended products for IBD research | Integrin beta 4 (ab182120) | APC Anti-GATA3 (ab225418) | IL-6 (ab259381) |
| Recommended products for rheumatology research | Interferon alpha/beta receptor 1 (ab124764) | CD74 carrier-free (ab289891) | TNF alpha (ab259410) |
| Recommended products for dermatology research | JAK3 (ab45141) | Alexa Fluor® 647 aryl hydrocarbon receptor (ab225358) IL-23R carrier-free (ab255964) |
Solutions for biomarker research: from ELISA kits to multiplex immunoassays
Autoimmune disease biomarkers are important for research, can serve as a diagnostic and are used to monitor the progress of drug therapy. See below our comprehensive portfolio of ELISA kits, antibody pairs, and FirePlex multiplex immunoassays for human samples to accelerate biomarker research in autoimmune diseases.
Product category |
Human SimpleStep ELISA® kits |
Human ELISA antibody pairs |
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Research goals | Rapidly validate autoimmune disease biomarkers to stratify patients by disease severity | Develop your own ELISA assay | Simultaneously profile key inflammation markers |
Benefit | With just one wash step and no compromise in performance, our highly sensitive ELISA kits give you reliable results in 90 minutes. | High-performing matched antibody pairs allow you to achieve consistent, specific and sensitive results, while carrier-free formulations give you more flexibility in terms of conjugation and assay setup. | High-throughput no-wash automation-friendly immunoassays, ideal for discovery, screening, and profiling projects. |
Common autoimmune markers | FirePlex®-384 Cytokines, Human Immunoassay Panel 1 (ab234897): IL-8, IFN gamma, IL-4, IL-1 beta, MCP1, TNF alpha, IL-10, IL-17A, IL-2, IL-6 FirePlex®-96 Inflammation, Human Immunoassay Panel (ab243550): IFN gamma, IL-1 beta, IL-6, IL-8, IL-10, IL-12p70, MCP1, TNF alpha FirePlex®-384 TGF-beta (Human, Mouse, Rat, NHP) Immunoassay Panel (ab270739) -TGF-B1, TGF-B2, and TGF-B3 | ||
IBD markers | |||
RA markers | |||
Lupus markers | |||
Psoriasis markers |
