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Immune evasion

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Cancer cells employ several immunosuppressive mechanisms to prevent the protective function of the immune system. For example, they can downregulate the expression of tumor antigens on their surface to evade recognition. To suppress immune function, these cells secrete paracrine mediators and suppressive cytokines which operate to inhibit the penetration of T cells into the tumor, inactivate effector T cells, and activate suppressor T cells. 

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