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Home Epigenetics and Nuclear Signaling

Epigenetics in disease

Product
  • Browse all related products

Epigenetics alterations occur in many human diseases, including cancer. Investigating epigenetic modifications in disease settings offers us valuable insights into underlying signaling pathways and disease progression, eventually contributing to the development of targeted therapies.

See how we can help you study epigenetics in the context of cancer and other diseases. Take a look at our latest webinars, guides, and posters covering such topics as cancer epigenetics, histone mutations, epigenetics in drug development and diagnostics, and many others.

To support ongoing drug discovery efforts, we provide an extensive portfolio of proteomic tools, from recombinant antibodies and proteins to ELISA kits and cell lines, to key targets in cancer epigenetics disease areas, including acute myeloid leukemia (AML), colorectal, prostate and breast cancers, glioma, melanoma and lung cancer (NSCLC).

Explore our highlighted epigenetics products to support drug discovery in AML, melanoma, and NSCLC:



AML

Melanoma

NSCLC

SimpleStep ELISA® kits

Achieve fast and reliable results with highly sensitive 90-minutes ELISAs with only a one-wash step protocol

Fit-3 (ab254507)

TIM-3 (ab231932)

CDKN2A (ab227903)

CSPG4 (ab267807)

EGFR (ab269558)

Met (c-Met)(ab277722)

Recombinant antibodies

Resolve reproducibility issues using recombinant antibodies with superior batch-to-batch consistency and long-term security of supply

MMP7 (ab207299)

BRCA1 (ab213929)

Melan-A (ab210546)

Melanoma gp100 (ab137078)

KRAS (ab275876)

ErbB2/HER2 (ab134182)

Knock-out cell lines

Save time and streamline your discovery workflow with reliable, well-characterized gene-edited cell lines.

EP300 knock-out K-562 (ab277897)

IL13RA2 knockout A375 (ab273381)


CD147 knockout A549 cell line (ab273748)

ATF3 knockout A549 cell line (ab266955)

Browse all related products

Features

Cancer epigenetics guide

Understand the role of key epigenetic targets and pathways in cancer with our in-depth guide covering histones, DNA and RNA modifications, and Polycomb and chromatin remodeling. 

Epigenetics in acute myeloid leukemia - poster

Unravel complex epigenetic mechanisms implicated in AML with our interactive pathway poster, highlighting key targets in this field and our products against these targets.

Cancer epigenetics poster

Explore key epigentics targets involved in the regulation of the biological processes critical to cancer with our interactive poster.

Epigenetics in drug development and diagnostics - digital talks

Hear A. Ganesan, Mark Eccleston, and Neil Michaud present their latest research on epigenetics in drug development and diagnostics ​

Histone mutations in cancer

Understand the role of H3K27M, H3K36M, and other histone mutations in cancer and accelerate your research with our recombinant monoclonal antibodies to key histone mutants.

Epigenetic landscape of acute myeloid leukemia - on-demand webinar

Hear from Richard Centore on the discovery of novel BAF inhibitors for cancer treatment and from ​Sydney Fobare on EZH2 inhibition in AML.

  • All
  • Articles
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Translational and Therapeutic Advances in Oncology and Epigenetics

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Video

Histone H3 mutations in cancer | Abcam

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Article

Epigenetics in acute myeloid leukemia

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Article

Cancer epigenetics guide

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Article

Cancer epigenetics poster

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Pathway

Stockholm 2018 212x70

Epigenetics in the Nervous System

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Video

Epigenetics in drug development and diagnostics - digital talks

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Video

MunicEpigeneticsMtg212x70

Drugging the Epitranscriptome as an Effective Anti-cancer Strategy

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Video

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