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DNA wraps around histones to form the nucleosome, the basic chromatin unit. Tightly packed heterochromatin forms structures such as telomeres and centromeres, whereas euchromatin features active genes. Chromatin immunoprecipitation (ChIP) is a popular application in the epigenetics field, and emerging techniques include 3C and derivatives. We provide antibodies and kits for chromatin extraction and ChIP.
Learn about chromatin structure, methods to study DNA accessibility and nucleosome positioning, and chromosome conformation techniques.
Learn the miCLIP basics, including protocol steps, advantages, and applications, and see the limitations of existing m6A detection methods.
See the detailed ATAC-seq protocol and learn more about this rapid and sensitive technique to assess genome-wide chromatin accessibility.
See the evolution of chromosome conformation capture (3C) method, including innovation in 3C methods and the future of 3C.