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Histones

Histones H3, H4, H2A and H2B form the nucleosome around which our DNA wraps. Histone tails are targets of epigenetic modification–including methylation and ubiquitination– that function to regulate gene expression. We offer tools to study histone modifications, such as antibodies and kits for ChIP, ChIP-seq, histone extraction and quantification.

Browse all products related to Histones

Features

A guide to histone modifications

Learn about histone modifications such as methylation, acetylation and phosphorylation, and how to study their role in Epigenetics.

Epigenetic modifications poster

Created in association with Tony Kouzarides and Andy Bannister of the Gurdon Institute.

Antibodies to histone modifications

Our expanding range of ChIP grade antibodies to histone modifications, from common targets to more recently discovered ones.

Histone extraction protocol

A step-by-step protocol for histone extraction for western blot including the preparation of histone proteins for electrophoresis.

HDAC classes and antibodies

Explore our range of HDAC antibodies, HDAC and SIRT activity assays and HDAC inhibitors.

Scientist of the month

Ever wondered what makes a world-leading scientist tick? Read our monthly interviews with top scientists in Epigenetics research.

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Protocols
Videos

Epigenetics conference calendar

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Epigenetic modifications poster

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Secondary Antibodies

Secondary antibodies optimized for co-IP western blotting

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Histone extraction protocol for western blot

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Epigenetics protocols

ChIP tips by Dr Andy Bannister of the Gurdon Institute

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Cross-linking chromatin immunoprecipitation (X-ChIP) protocol

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ChIP and ChIP-seq kits: from high sensitivity to fast protocols.

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Histone western blot protocol

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Chromatin preparation from tissues for ChIP

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Immunoprecipitation

Immunoprecipitation protocol

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Techniques and tools to study histone modifications

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Highly specific, peptide array-tested histone modification antibodies.

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Histone modifications and where to find them

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Chromatin structure and function

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Advantages of our anti-histone H3 antibody (ab1791)

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Chromatin and histone extraction kits

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Epigenetic mechanisms webinar-

Epigenetic Mechanisms in Early Mammalian Development

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An Introduction to ChIP Principles with Troubleshooting Tips

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A Beginner's Guide to ChIP

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Applications of ChIP

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MunicEpigeneticsMtg212x70

Regulation of Bivalent Domains by Histone Modifications

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A Step-by-Step Guide to ChIP-Seq Data Analysis

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The Role of Polycombs in Cancer

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Assays for histone methyltransferases & demethylases

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Histone modifications guide

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Anti-histone H3: the most cited H3 antibody

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Histone methyltransferase and demethylase inhibitors

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ChIP troubleshooting tips

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Getting started with Chromatin Conformation Capture (3C)

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Protocols and troubleshooting tips, to help get the best from our antibodies

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How researchers are using our histone antibodies

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Native chromatin immunoprecipitation protocol

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ChIP 2.0: Guide to advanced chromatin immunoprecipitation

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Epigenetic histone Modifications interactive pathway

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London Chromatin Club: ten years of sponsorship

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Sharon Dent: Scientist of the month March 2015

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Marianne Rots: Scientist of the month February 2015

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Top Epigenetics articles: February 2015

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Top Epigenetics articles: January 2015

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Genome editing in Epigenetics and ncRNA research

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Top Epigenetics articles: December 2014

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Top Epigenetics articles: November 2014

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Top Epigenetics articles: October 2014

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Top Epigenetics articles: September 2014

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Top Epigenetics articles: August 2014

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Top Epigenetics articles: July 2014

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Top Epigenetics articles: June 2014

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Top Epigenetics articles: May 2014

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Combined ChIP and bisulfite sequencing

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Epigenetics round-up of 2014

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chip grade antibodies

Browse over 600 ChIP grade antibodies

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ChIP using plant samples - Arabidopsis

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John Gurdon: Scientist of the month October 2014

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Construct Illumina® sequencing libraries from as little as 0.2 ng of input DNA

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Robert Schneider: Scientist of the month September 2014

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Tony Kouzarides: Scientist of the month August 2014

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Rob Klose: Scientist of the month July 2014

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An overview of HDAC classes and antibodies

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Beyond ChIP Studies: the evolution of chromosome conformation capture

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Epigenetics glossary

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Histone acetyltransferase activity assay kit

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Advances in ChIP-Seq analysis with small samples

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Conference report – Chromatin: from nucleosomes to chromosomes

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HDAC inhibitors

HDAC inhibitors

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HDAC/SIRT activity assays

HDAC & SIRT activity kits

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Histone H3 ChIP-grade antibodies

ChIP-grade antibodies to H3K27

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Histone H3 ChIP-grade antibodies

ChIP-grade antibodies to H3K4

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Histone H3 ChIP-grade antibodies

ChIP-grade antibodies to H3K9

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Histone antibodies at Abcam

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