Anti-Retinal S antigen antibody (ab3435)

Anti-Retinal S antigen antibody
See all Retinal S antigen primary antibodies

Rabbit polyclonal to Retinal S antigen

Rabbit

Detects recombinant bovine visual Arrestin.

Suitable for: WB, IP, IHC-P, ICC/IFmore details

Reacts with: Mouse, Sheep, Cow, Human
Predicted to work with: Rat, Dog, Pig

Synthetic peptide corresponding to Rat Retinal S antigen aa 347-363.
Sequence:

EVATEVPFRLMHPQPED

(Peptide available as ab4974)

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Liquid

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 99% PBS

Immunogen affinity purified

Vision involves the conversion of light into electrochemical signals that are processed by the retina and subsequently sent to, and interpreted by, the brain. The process of converting light to an electrochemical signal begins when the membrane-bound protein, rhodopsin, absorbs light within the retina. Photoexcitation of rhodopsin causes the cytoplasmic surface of the protein to become catalytically active. In the active state, rhodopsin activates transducin, a GTP binding protein. Once activated, transducin promotes the hydrolysis of cGMP by phosphodiesterase (PDE). The decrease of intracellular cGMP concentrations causes the ion channels within the outer segment of the rod or cone to close, thus causing membrane hyperpolarization and, eventually, signal transmission. Rhodopsin’s activity is believed to be shut off by its phosphorylation followed by binding of the soluble protein arrestin. Arrestins are cytosolic proteins that are involved in G protein-coupled receptor (GPCR) desensitization. Arrestin binding to activated GPCRs is phosphorylation dependent and, once bound, uncouple the GPCR from the associated heterotrimeric G proteins. There are currently 4 known mammalian isoforms, beta-Arrestin 1 (Arrestin 2), beta-Arrestin 2 (Arrestin 3), visual Arrestin (Arrestin 1), and cone arrestin. The beta- isoforms are ubiquitously expressed and are known to interact with acetylcholine and adrenergic receptors. Visual and cone Arrestins are found to interact directly with transducin.

Polyclonal

IgG

• Signal Transduction
• Signaling Pathway
• G Protein Signaling
• Heterotrimeric G Proteins
• Regulators

• Tags & Cell Markers
• Cell Type Markers
• Other Cell Types

• Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
• Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

• Retinal S antigen peptide (ab4974)