Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab4974 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and rat S-arrestin, catalog ab3435. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names
    • 48 kDa protein
    • Arrestin
    • Arrestin 1
    • ARRS_HUMAN
    • Retinal S antigen (48 KDa protein)
    • Retinal S-antigen
    • Rod photoreceptor arrestin
    • RP47
    • S antigen
    • S antigen retina and pineal gland (arrestin)
    • S arrestin
    • S-AG
    • S-arrestin
    • SAG
    see all
  • Function
    Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase.
  • Tissue specificity
    Retina and pineal gland.
  • Involvement in disease
    Defects in SAG are a cause of congenital stationary night blindness Oguchi type 1 (CSNBO1) [MIM:258100]; also known as Oguchi disease. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. CSNBO is an autosomal recessive form associated with fundus discoloration and abnormally slow dark adaptation.
  • Sequence similarities
    Belongs to the arrestin family.
  • Information by UniProt

References

ab4974 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Answer

Thank you for contacting us and for your interest in our products.

I am sorry to confirm that as far as we are aware, ab4974 Retinal S antigen peptidehas never been tested in this type of application.This has beentested as a blocking peptide only. All tested applications covered by our 6 month guarantee are specified on our datasheets, and these are updated as soon as any new information is brought to our attention.

I am sorry we could not confirm this protein for your applications on this occasion.

If you do decide to try the protein in your experiments, we like to encourage all of our customers to submit an Abreview via the online product datasheet. We always appreciate customer feedback, whether positive or negative, and we make all product information available to researchers. Plus, each Abreview earns Abpoints that can be used for discounts on future purchases or rewards such as Amazon.com gift certificates.

To find out more about our Abreview system, please see the following link:

https://www.abcam.com/abreviews

Please do not hesitate to contact me for any further advice or information.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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