Key features and details
- Rabbit polyclonal to Retinoblastoma binding protein 6
- Suitable for: IHC-P
- Reacts with: Rat
- Isotype: IgG
Product nameAnti-Retinoblastoma binding protein 6 antibody
See all Retinoblastoma binding protein 6 primary antibodies
DescriptionRabbit polyclonal to Retinoblastoma binding protein 6
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Rat
Predicted to work with: Mouse, Human
- Rat kidney and testis tissues.
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We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: 1% BSA, 50% Glycerol
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab217283 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/100 - 1/500.|
FunctionE3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth.
Tissue specificityHighly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer.
PathwayProtein modification; protein ubiquitination.
Sequence similaritiesContains 1 CCHC-type zinc finger.
Contains 1 DWNN domain.
Contains 1 RING-type zinc finger.
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated by NEK6.
Cellular localizationNucleus > nucleolus. Chromosome. Cytoplasm > cytoskeleton > centrosome. Colocalizes with mitotic chromosomes. Co-localizes with NEK6 in the centrosome.
- Information by UniProt
- DKFZp686P0638 antibody
- DKFZp761B2423 antibody
- E3 ubiquitin-protein ligase RBBP6 antibody
Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat testis tissue labeling Retinoblastoma binding protein 6 with ab217283 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.
Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat kidney tissue labeling Retinoblastoma binding protein 6 with ab217283 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.
ab217283 has not yet been referenced specifically in any publications.