• Product name

    Anti-Retinoblastoma binding protein 6 antibody
    See all Retinoblastoma binding protein 6 primary antibodies
  • Description

    Rabbit polyclonal to Retinoblastoma binding protein 6
  • Host species

  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment corresponding to Human Retinoblastoma binding protein 6 aa 51-97.


    Database link: Q7Z6E9

  • Positive control

    • WB: Mouse brain tissue lysate. IHC-P: Human cervical cancer and testis tissue. ICC/IF: HeLa cells.



Our Abpromise guarantee covers the use of ab237514 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/5000. Predicted molecular weight: 202 kDa.
IHC-P 1/20 - 1/200.
ICC/IF 1/50 - 1/200.


  • Function

    E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth.
  • Tissue specificity

    Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer.
  • Pathway

    Protein modification; protein ubiquitination.
  • Sequence similarities

    Contains 1 CCHC-type zinc finger.
    Contains 1 DWNN domain.
    Contains 1 RING-type zinc finger.
  • Post-translational

    Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated by NEK6.
  • Cellular localization

    Nucleus > nucleolus. Chromosome. Cytoplasm > cytoskeleton > centrosome. Colocalizes with mitotic chromosomes. Co-localizes with NEK6 in the centrosome.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZp686P0638 antibody
    • DKFZp761B2423 antibody
    • E3 ubiquitin-protein ligase RBBP6 antibody
    • MY038 antibody
    • P2P R antibody
    • P2PR antibody
    • p53 associated cellular protein of testis antibody
    • p53-associated cellular protein of testis antibody
    • p53-associated cellular protein, testis-derived antibody
    • PACT antibody
    • Proliferation potential related protein antibody
    • Proliferation potential-related protein antibody
    • Protein P2P R antibody
    • Protein P2P-R antibody
    • Protein P2PR antibody
    • Protein RBQ 1 antibody
    • Protein RBQ1 antibody
    • RB binding protein 6, ubiquitin ligase antibody
    • RB binding Q protein 1 antibody
    • RBBP 6 antibody
    • Rbbp6 antibody
    • RBBP6_HUMAN antibody
    • RBQ 1 antibody
    • RBQ-1 antibody
    • RBQ1 antibody
    • Retinoblastoma binding protein 6 isoform 3 antibody
    • Retinoblastoma binding Q protein 1 antibody
    • Retinoblastoma-binding protein 6 antibody
    • Retinoblastoma-binding Q protein 1 antibody
    • SNAMA antibody
    • SNAMA, Drosophila, homolog of antibody
    see all


  • Anti-Retinoblastoma binding protein 6 antibody (ab237514) at 1/500 dilution + Mouse brain tissue lysate

    Goat polyclonal to rabbit IgG at 1/50000 dilution

    Predicted band size: 202 kDa

  • Paraffin-embedded human cervical cancer tissue stained for Retinoblastoma binding protein 6 using ab237514 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human testis tissue stained for Retinoblastoma binding protein 6 using ab237514 at 1/100 dilution in immunohistochemical analysis.

  • HeLa (Human epithelial cell line from cervix adenocarcinoma) cells stained for Retinoblastoma binding protein 6 (green) using ab237514 at 1/100 dilution in ICC/IF. Secondary antibody is an Alexa Fluor® 488-conjugated Goat Anti-Rabbit IgG (H+L).


ab237514 has not yet been referenced specifically in any publications.

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