Overview

  • Product name

    Anti-Retinoic Acid Receptor gamma antibody
    See all Retinoic Acid Receptor gamma primary antibodies
  • Description

    Rabbit polyclonal to Retinoic Acid Receptor gamma
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment within Human Retinoic Acid Receptor gamma aa 1-245. The exact sequence is proprietary.
    Database link: P13631

  • Positive control

    • Human prostate tissue; A549, HCT116 and Neuro2A whole cell lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab191368 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 50 kDa.
IHC-P Use a concentration of 7.5 µg/ml.

Target

  • Function

    Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function.
  • Sequence similarities

    Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Domain

    Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • NR1B3 antibody
    • Nuclear receptor subfamily 1 group B member 3 antibody
    • RAR gamma antibody
    • RAR-gamma antibody
    • RARC antibody
    • Rarg antibody
    • RARG_HUMAN antibody
    • Retinoic acid receptor gamma 2 antibody
    • Retinoic acid receptor gamma antibody
    • Retinoic acid receptor, gamma antibody
    see all

Images

  • Anti-Retinoic Acid Receptor gamma antibody (ab191368) at 1/1000 dilution + Neuro2A whole cell lysate at 30 µg

    Predicted band size: 50 kDa



    10 % SDS-PAGE

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human prostate tissue labeling  Retinoic Acid Receptor gamma with ab191368 at 7.5 µg/ml.

  • All lanes : Anti-Retinoic Acid Receptor gamma antibody (ab191368) at 1/1000 dilution

    Lane 1 : A549 whole cell lysate
    Lane 2 : HCT116 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 50 kDa



    10 % SDS-PAGE

References

This product has been referenced in:

  • Chen F  et al. Retinoic acid signaling is essential for airway smooth muscle homeostasis. JCI Insight 3:N/A (2018). Read more (PubMed: 30135301) »
  • Mu Q  et al. RIP140/PGC-1a axis involved in vitamin A-induced neural differentiation by increasing mitochondrial function. Artif Cells Nanomed Biotechnol 46:806-816 (2018). Read more (PubMed: 29513101) »
See all 2 Publications for this product

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