Product nameAnti-Retinoid X Receptor beta antibody - ChIP Grade
See all Retinoid X Receptor beta primary antibodies
DescriptionRabbit polyclonal to Retinoid X Receptor beta - ChIP Grade
Tested applicationsSuitable for: ChIP, IHC - Wholemount, IP, WBmore details
Species reactivityReacts with: Mouse, Cow, Human
Predicted to work with: Rat, Dog
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.05% Sodium azide
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Retinoic & Retinoid
Our Abpromise guarantee covers the use of ab5793 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ChIP||Use at an assay dependent concentration.|
|IHC - Wholemount||Use at an assay dependent concentration.|
|IP||Use at an assay dependent concentration.|
|WB||1/1000. Detects a band of approximately 50 kDa (predicted molecular weight: 63 kDa).
Detects a band of approximately 50 kDa representing RXR beta from COS cells transfected with the human gene (predicted molecular weight: 63 kDa).
|EMSA||Use at an assay dependent concentration.
Gel shift assays reveal supershifting of vitamin D receptor (VDR)/RXR beta/vitamin D receptor response element (VDRE) complexes when ab5739 is preincubated with RXR beta prior to addition of VDR.
RelevanceRetinoid X receptors (RXRs) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptor proteins which exert their effects by binding to specific DNA response elements, thus regulating gene expression in target cells. The RXR subfamily consists of at least three similar genes, RXR alpha, RXR beta and RXR gamma, all of which control transcription of target genes mediated by retinoids. RXR beta controls expression of many genes that respond to hormones and vitamins, including thyroid hormone, estrogen, retinoids and vitamin D. RXR beta controls a wide array of genes because of its ability to heterodimerize with other hormone receptors including the thyroid hormone receptor (THR), vitamin D receptor (VDR) and retinoic acid receptor (RAR).
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ab5793 has not yet been referenced specifically in any publications.