Overview

  • Product name

    Reversan, MRP1 and P-glycoprotein inhibitor
  • Description

    Selective MRP1 and P-glycoprotein inhibitor. Chemosensitizing agent.
  • Biological description

    Selective MRP1 and P-glycoprotein inhibitor. Chemosensitizing agent. Increases the sensitivity of MRP1-overexpressing tumor cells to doxorubicin (ab120629), vincristine (ab120226) and etoposide (ab120227). Shows chemosensitizing, antitumor effects in vivo.
  • Purity

    > 99%
  • CAS Number

    313397-13-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[3-(4-Morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
  • Molecular weight

    441.53
  • Molecular formula

    C26H27N5O2
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 5 mM and in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1COCCN1CCCNC(=O)C2=C3N=C(C=C(N3N=C2)C4=CC=CC=C4)C5=CC=CC=C5
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Helms HC  et al. An electrically tight in vitro blood-brain barrier model displays net brain-to-blood efflux of substrates for the ABC transporters, P-gp, Bcrp and Mrp-1. AAPS J 16:1046-55 (2014). Read more (PubMed: 24934296) »
  • Burkhart CA  et al. Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma. Cancer Res 69:6573-80 (2009). Read more (PubMed: 19654298) »
  • Koeller KM  et al. Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation. Chem Biol 10:397-410 (2003). Read more (PubMed: 12770822) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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