Overview

  • Product name

  • Description

    Guinea pig polyclonal to RFRP
  • Host species

    Guinea pig
  • Tested applications

    Suitable for: IHC-Frmore details
  • Species reactivity

    Reacts with: Sheep
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide corresponding to Human RFRP aa 124-131 conjugated to keyhole limpet haemocyanin.
    Sequence:

    VPNLPQRF


    Database link: Q9HCQ7

  • Positive control

    • IHC-P: Sheep hypothalamus tissue.
  • General notes

    Previously labelled as NPVF.

Properties

  • Form

    Lyophilised:Reconstitute in 50 µl sterile water. Centrifuge to remove any insoluble material. After reconstitution, aliquot and store at -20°C for a higher stability.
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Concentration information loading...
  • Purity

    Whole antiserum
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab228496 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr 1/2000.

Target

  • Function

    Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP, but RFRP-2 shows no inhibitory activity. Neuropeptide RFRP-1 induces secretion of prolactin in rats. Neuropeptide NPVF blocks morphine-induced analgesia.
  • Tissue specificity

    Isoform 1 is specifically expressed in the retina. Neuropeptides RFRP-1 and NPVF are detected in the hypothalamus.
  • Sequence similarities

    Belongs to the FARP (FMRFamide related peptide) family.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • C7orf9 antibody
    • Neuropeptide NPSF antibody
    • Neuropeptide NPVF antibody
    • Neuropeptide RFRP-1 antibody
    • Neuropeptide RFRP-2 antibody
    • Neuropeptide RFRP-3 antibody
    • Neuropeptide VF antibody
    • NPVF antibody
    • RFRP antibody
    • RFRP_HUMAN antibody
    see all

Images

  • 4% PFA-fixed frozen sheep hypothalamus tissue stained for RFRP (green) using ab228496 at 1/2000 dilution in immunohistochemical analysis.

  • 4% PFA-fixed frozen sheep hypothalamus tissue stained for RFRP (green) using ab228496 at 1/2000 dilution in immunohistochemical analysis. Staining is not affected by preadsorption with Kisspeptin.

  • 4% PFA-fixed frozen sheep hypothalamus tissue stained for RFRP (green) using ab228496 at 1/2000 dilution in immunohistochemical analysis. Staining is not affected by preadsorption with Prolactin-releasing peptide (PrRP).

  • 4% PFA-fixed frozen sheep hypothalamus tissue stained for RFRP (green) using ab228496 at 1/2000 dilution in immunohistochemical analysis. Staining is not affected by preadsorption with NFF peptide.

References

ab228496 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab228496.
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