Key features and details
- Novel, non-nucleoside DNA methyltransferase inhibitor (DNMT)
- CAS Number: 48208-26-0
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameRG 108, non-nucleoside DNA methyltransferase inhibitor (DNMT)
DescriptionNovel, non-nucleoside DNA methyltransferase inhibitor (DNMT)
Novel, non-nucleoside DNA methyltransferase (DNMT) inhibitor, capable of interacting with the DNMT1 active site (IC50 = 115 nM). Inhibits DNA methylation in human cancer cell lines. Reactivates several epigenetically silenced tumour suppressor genes in vitro. Capable of enhancing the efficiency of induced pluripotent stem cell (iPS) generation.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141013 has been referenced in 4 publications.
- Liu K et al. DNA Methylation May be Involved in the Analgesic Effect of Hyperbaric Oxygen via Regulating FUNDC1. Pain Res Manag 2020:1528362 (2020). PubMed: 32148597
- Zanconato F et al. Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4. Nat Med 24:1599-1610 (2018). PubMed: 30224758
- Saunders J et al. Negative Evidence for a Functional Role of Neuronal DNMT3a in Persistent Pain. Front Mol Neurosci 11:332 (2018). PubMed: 30258352
- Bialesova L et al. Epigenetic Regulation of PLIN 1 in Obese Women and its Relation to Lipolysis. Sci Rep 7:10152 (2017). PubMed: 28860604