RG7388, p53-MDM2 interaction inhibitor (ab219378)

Overview

  • Product name

    RG7388, p53-MDM2 interaction inhibitor
  • Description

    Potent, selective inhibitor of p53-MDM2 interaction
  • Alternative names

    • Idasanutlin
    • RG 7388
    • RO 5503781
    • RO5503781
  • Biological description

    Potent, selective inhibitor of p53-MDM2 interaction. Blocks p53−MDM2 binding and effectively activates the p53 pathway, leading to cell cycle arrest and/or apoptosis in cell lines expressing wild-type p53 and tumor growth inhibition or regression of osteosarcoma xenografts in nude mice.

  • Purity

    > 99%
  • CAS Number

    1229705-06-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino]-3-methoxybenzoic acid
  • Molecular weight

    616.48
  • Molecular formula

    C31N29Cl2F2N3O4
  • PubChem identifier

    53358942
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 10 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)(C)C[C@H]1[C@]([C@H]([C@@H](N1)C(=O)NC2=C(C=C(C=C2)C(=O)O)OC)C3=C(C(=CC=C3)Cl)F)(C#N)C4=C(C=C(C=C4)Cl)F
  • Source

    Synthetic

References

This product has been referenced in:

  • Chen L  et al. Pre-clinical evaluation of the MDM2-p53 antagonist RG7388 alone and in combination with chemotherapy in neuroblastoma. Oncotarget 6:10207-21 (2015). Read more (PubMed: 25844600) »
  • Higgins B  et al. Preclinical optimization of MDM2 antagonist scheduling for cancer treatment by using a model-based approach. Clin Cancer Res 20:3742-52 (2014). Read more (PubMed: 24812409) »
  • Ding Q  et al. Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development. J Med Chem 56:5979-83 (2013). Read more (PubMed: 23808545) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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