Key features and details
- Potent, selective inhibitor of p53-MDM2 interaction
- CAS Number: 1229705-06-9
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 10 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Product nameRG7388, p53-MDM2 interaction inhibitor
DescriptionPotent, selective inhibitor of p53-MDM2 interaction
- RG 7388
- RO 5503781
Potent, selective inhibitor of p53-MDM2 interaction. Blocks p53−MDM2 binding and effectively activates the p53 pathway, leading to cell cycle arrest and/or apoptosis in cell lines expressing wild-type p53 and tumor growth inhibition or regression of osteosarcoma xenografts in nude mice.
Chemical name4-[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino]-3-methoxybenzoic acid
Storage instructionsShipped at 4°C. Store at -20°C. Store under desiccating conditions.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 10 mM (with warming)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab219378 has not yet been referenced specifically in any publications.