RGDS peptide, Fibronectin inhibitor (ab230365)

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Overview

  • Product name

    RGDS peptide, Fibronectin inhibitor

  • Description

    Fibronectin inhibitor

  • Alternative names

    • Fibronectin inhibitor
    • H-Arg-Gly-Asp-Ser-OH

  • Biological description

    Conserved tetrapeptide sequence Arg-Gly-Asp-Ser (RGDS) found on fibronectin, fibrinogen alpha and von Willebrand factor. Associates with integrins on the cell surface. Inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen alpha and von Willebrand factor.

  • Purity

    > 95%

  • CAS Number

    91037-65-9

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    L-arginylglycyl-L-α-aspartyl-L-serine

  • Molecular weight

    433.42

  • Molecular formula

    C15H27N7O8

  • Sequence

    L-Arginylglycyl-L-α-aspartyl-L-serine

  • PubChem identifier

    107775

  • Storage instructions

    Shipped at 4°C. Store at -20°C.

  • Solubility overview

    30, 25 and 50 mg/ml in ethanol, DMSO and dimethyl formamide respectively, and 10 mg/ml in PBS (pH 7.2).

  • Handling

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    [H]N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O

  • Source

    Synthetic

References

This product has been referenced in:

  • Moon C  et al. Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Respir Res 10:18 (2009). Read more (PubMed: 19272161) »
  • Ginsberg M  et al. Inhibition of fibronectin binding to platelets by proteolytic fragments and synthetic peptides which support fibroblast adhesion. J Biol Chem 260:3931-6 (1985). Read more (PubMed: 3980461) »
  • Haverstick DM  et al. Inhibition of platelet adhesion to fibronectin, fibrinogen, and von Willebrand factor substrates by a synthetic tetrapeptide derived from the cell-binding domain of fibronectin. Blood 66:946-52 (1985). Read more (PubMed: 3876125) »
  • Gartner TK & Bennett JS The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated platelets. J Biol Chem 260:11891-4 (1985). Read more (PubMed: 2995350) »

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