RGFP 966, HDAC3 inhibitor (ab144819)
Key features and details
- Potent, selective HDAC3 inhibitor
- CAS Number: 1357389-11-7
- Purity: > 99%
Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
RGFP 966, HDAC3 inhibitor -
Description
Potent, selective HDAC3 inhibitor -
Purity
> 99% -
CAS Number
1357389-11-7 -
Chemical structure
Properties
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Chemical name
(E)-N-(2-amino-4-fluorophenyl)-3-[1-[(E)-3-phenylprop-2-enyl]pyrazol-4-yl]prop-2-enamide
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Molecular weight
362.40 -
Molecular formula
C21H19FN4O -
PubChem identifier
56650312 -
Storage instructions
Store at -20°C (desiccating conditions). -
Solubility overview
Soluble in DMSO to 100 mM
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Handling
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC=C(C=C1)/C=C/CN2C=C(C=N2)/C=C/C(=O)NC3=C(C=C(C=C3)F)N -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (5)
ab144819 has been referenced in 5 publications.
- Yonamine CY et al. Postmortem Brains from Subjects with Diabetes Mellitus Display Reduced GLUT4 Expression and Soma Area in Hippocampal Neurons: Potential Involvement of Inflammation. Cells 12:N/A (2023). PubMed: 37174649
- Olivieri D et al. Cooperation between HDAC3 and DAX1 mediates lineage restriction of embryonic stem cells. EMBO J 40:e106818 (2021). PubMed: 33909924
- Zylicz JJ et al. The Implication of Early Chromatin Changes in X Chromosome Inactivation. Cell 176:182-197.e23 (2019). PubMed: 30595450
- Shang A et al. Inhibition of histone deacetylase 3 via RGFP966 facilitates cortical plasticity underlying unusually accurate auditory associative cue memory for excitatory and inhibitory cue-reward associations. Behav Brain Res N/A:N/A (2018). PubMed: 29860001
- Sharma M et al. Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor kappa B. Sci Rep 5:16616 (2015). PubMed: 26577291