Overview

  • Product name

  • Description

    Rabbit polyclonal to RGR
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except SSTR1 (50%).
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Horse, Cow, Dog, Pig, Monkey, Common marmoset
  • Immunogen

    Synthetic peptide corresponding to Human RGR (extracellular). (16 amino acid peptide from the 1st extracellular domain).
    Database link: P47804

  • Positive control

    • Human retina tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab188948 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Relevance

    RGR is a putative retinal G-protein coupled receptor and is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. RGR acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal (the reverse isomerization occurs with rhodopsin in retinal photoreceptor cells). RGR is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Cellular localization

    Cell Membrane; Multi-pass membrane protein
  • Database links

  • Alternative names

    • hRGR antibody
    • Ral GDS related protein antibody
    • Retinal G protein coupled receptor antibody
    • RGR-opsin antibody
    • RP44 antibody
    • RPE retinal G protein coupled receptor antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human retina tissue labeling RGR with ab188948 at 10 µg/ml.

References

ab188948 has not yet been referenced specifically in any publications.

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