Key features and details
- Rabbit polyclonal to RGR
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-RGR antibody
DescriptionRabbit polyclonal to RGR
SpecificityBLAST analysis of the peptide immunogen showed no homology with other Human proteins, except SSTR1 (50%).
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Horse, Cow, Dog, Pig, Monkey, Common marmoset
Synthetic peptide corresponding to Human RGR (extracellular). (16 amino acid peptide from the 1st extracellular domain).
Database link: P47804
- Human retina tissue.
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We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.1% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab188948 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
RelevanceRGR is a putative retinal G-protein coupled receptor and is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. RGR acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal (the reverse isomerization occurs with rhodopsin in retinal photoreceptor cells). RGR is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms.
Cellular localizationCell Membrane; Multi-pass membrane protein
- hRGR antibody
- Ral GDS related protein antibody
- Retinal G protein coupled receptor antibody
ab188948 has not yet been referenced specifically in any publications.