Overview

  • Product name

  • Description

    Goat polyclonal to RGS1
  • Host species

    Goat
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide:

    NLLNDLQANSLK

    , corresponding to C terminal amino acids 185-196 of Human RGS1.

  • Positive control

    • HepG2 lysate
  • General notes

    Principal Names – RGS1; regulator of G-protein signalling 1; 1R20; BL34; IER1; IR20; 1R20; Regulator of G-protein signaling 1 Official Gene Symbol - RGS1 GenBank Accession Number – NP_002913 LocusLink ID - 5996 (human); 50778 (mouse) Gene Ontology terms - GTPase activator; calmodulin binding; G-protein signaling, adenylate cyclase inhibiting pathway; immune response; signal transduction; plasma membrane

Properties

Applications

Our Abpromise guarantee covers the use of ab2715 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 25 kDa.

Approx 25kDa band seen in HepG2 lysate.

Target

  • Function

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation.
  • Tissue specificity

    B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high.
  • Sequence similarities

    Contains 1 RGS domain.
  • Post-translational
    modifications

    Could be phosphorylated. Might be functionally regulated by protein kinase(s).
  • Information by UniProt
  • Database links

  • Alternative names

    • 1R20 antibody
    • B cell activation protein BL34 antibody
    • B-cell activation protein BL34 antibody
    • BL34 antibody
    • Early response protein 1R20 antibody
    • IER 1 antibody
    • IER1 antibody
    • Immediate early response 1 B cell specific antibody
    • immediate-early response 1, B-cell specific antibody
    • IR20 antibody
    • Regulator of G protein signalling 1 antibody
    • Regulator of G-protein signaling 1 antibody
    • RGS 1 antibody
    • RGS1 antibody
    • RGS1_HUMAN antibody
    see all

References

ab2715 has not yet been referenced specifically in any publications.

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