Overview

  • Product name

    Anti-RGS17 / RGSZ2 antibody
    See all RGS17 / RGSZ2 primary antibodies
  • Description

    Rabbit polyclonal to RGS17 / RGSZ2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide: EVSLDSRVRE VINRNLLDPN PHMYEDAQLQ IYTLMHRDSF PRFLNSQIYK SFVESTAGSS SES, corresponding to amino acids 148-210 of Human RGS17/ RGSZ2 (NP_036551).

  • Positive control

    • 293T, A431, H1299, HeLa, HepG2, MOLT4 and Raji cell lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab96675 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 24 kDa.

Target

  • Function

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins.
  • Tissue specificity

    Predominantly expressed in the cerebellum. Also expressed in the cortex and medulla. Weakly expressed in a number of peripheral tissues notably spleen, lung and leukocytes.
  • Sequence similarities

    Contains 1 RGS domain.
  • Post-translational
    modifications

    Fatty acylated. Heavily palmitoylated in the cysteine string motif.
    N- and O-glycosylated in synapsomal membranes.
    Serine phosphorylated in synapsomal membranes.
    Sumoylated by SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits.
  • Cellular localization

    Membrane. Nucleus. Cytoplasm. Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation.
  • Information by UniProt
  • Database links

  • Alternative names

    • hRGS17 antibody
    • Regulator of G protein signalling 17 antibody
    • Regulator of G protein signalling Z2 antibody
    • Regulator of G-protein signaling 17 antibody
    • RGS-17 antibody
    • RGS17 antibody
    • RGS17_HUMAN antibody
    • RGSZ2 antibody
    see all

Images

  • Anti-RGS17 / RGSZ2 antibody (ab96675) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size: 24 kDa



    12% SDS PAGE

References

ab96675 has not yet been referenced specifically in any publications.

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