Overview

  • Product name
    Anti-RGS19 antibody - C-terminal
    See all RGS19 primary antibodies
  • Description
    Rabbit polyclonal to RGS19 - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rhesus monkey
  • Immunogen

    Synthetic peptide within Human RGS19 (C terminal). The exact sequence is proprietary. Conjugated to a protein carrier.
    Database link: P49795

  • Positive control
    • WB: RGS19-transfected HEK-293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab228611 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 25 kDa.

Target

  • Function
    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
  • Tissue specificity
    Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
  • Sequence similarities
    Contains 1 RGS domain.
  • Post-translational
    modifications
    Fatty acylated. Heavily palmitoylated in the cysteine string motif.
    Phosphorylated, mainly on serine residues.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • G alpha interacting protein antibody
    • G protein signalling regulator 19 antibody
    • G protein, alpha-interacting protein antibody
    • G-alpha-interacting protein antibody
    • GAIP antibody
    • GNAI3IP antibody
    • Guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein antibody
    • Regulator of G protein signalling 19 antibody
    • Regulator of G-protein signaling 19 antibody
    • RGS19 antibody
    • RGS19_HUMAN antibody
    • RGSGAIP antibody
    see all

Images

  • All lanes : Anti-RGS19 antibody - C-terminal (ab228611) at 1/500 dilution

    Lane 1 : Non-transfected HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) cell lysate
    Lane 2 : RGS19-transfected HEK-293T cell lysate

    Developed using the ECL technique.

    Predicted band size: 25 kDa



    12% SDS-PAGE

References

ab228611 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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