Overview

  • Product name

  • Description

    Rabbit polyclonal to RGS2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IPmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Pig, Rhesus monkey
  • Immunogen

    Recombinant fragment within Human RGS2 (internal sequence). The exact sequence is proprietary.
    Database link: P41220

  • Positive control

    • IP: U-87 MG whole cell extract. WB: U-87 MG whole cell extract.

Properties

Applications

Our Abpromise guarantee covers the use of ab227251 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 24 kDa.
IP 1/100 - 1/500.

Target

  • Function

    Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320).
  • Tissue specificity

    Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).
  • Sequence similarities

    Contains 1 RGS domain.
  • Post-translational
    modifications

    Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.
  • Cellular localization

    Cell membrane. Mitochondrion and Cell membrane. Cytoplasm. Nucleus, nucleolus.
  • Information by UniProt
  • Database links

  • Alternative names

    • Basic helix-loop-helix phosphoprotein G0S8 antibody
    • Cell growth inhibiting protein 31 antibody
    • Cell growth-inhibiting gene 31 protein antibody
    • G0 to G1 switch regulatory 8 24kD antibody
    • G0/G1 switch regulatory protein 8 antibody
    • G0S8 antibody
    • GOS8 antibody
    • OTTHUMP00000060765 antibody
    • Regulator of G protein signaling 2 antibody
    • Regulator of G protein signalling 2 24kD antibody
    • Regulator of G-protein signaling 2 antibody
    • Regulators of G protein signaling XRGSVI antibody
    • RGS 2 antibody
    • RGS2 antibody
    • RGS2_HUMAN antibody
    see all

Images

  • RGS2 was immunoprecipitated from U-87 MG (human glioblastoma-astrocytoma epithelial cell line) whole cell extract with 5 µg ab227251. Western blot was performed from the immunoprecipitate using ab227251. Anti-Rabbit IgG was used as a secondary reagent.

    Lane 1: Control IgG IP in U-87 MG whole cell extract.

    Lane 2: ab227251 IP in U-87 MG whole cell extract.

  • Anti-RGS2 antibody (ab227251) at 1/1000 dilution + U-87 MG (human glioblastoma-astrocytoma epithelial cell line) whole cell extract at 30 µg

    Predicted band size: 24 kDa



    12% SDS-PAGE gel.

References

ab227251 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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