RGS7 inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP bound form. Activity on G(o) alpha is specifically enhanced by the RGS6/GNG5 dimer. RGS7 may play a role in synaptic vesicle exocytosis and may play an important role in the rapid regulation of neuronal excitability and the cellular responses to short lived stimulations.
Immunohistochemical analysis of Formalin/PFA-fixed paraffin-embedded Human brain tissue labeling RGS7 with ab170801 at a 1/10 dilution followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot - Anti-RGS7 antibody - C-terminal (ab170801)
Anti-RGS7 antibody - C-terminal (ab170801) at 1/100 dilution + K562 cell line lysates at 35 µg