Overview

  • Product name

    Rhyncholphylline, Ca2+ channel blocker
  • Description

    Ca2+ channel blocker. Non-competitive NMDA antagonist.
  • Biological description

    Ca2+ channel blocker. Non-competitive NMDA antagonist (IC50 = 43.2 μM). Inhibits glutamate-induced neuronal death. Inhibits dopamine-induced apoptosis. Reduces endothelin-induced cerebral arteriole contraction. Reduces cerebral blood pressure and shows anticonvulsant effects in vivo. Orally active. Blood-brain barrier permeable.
  • Purity

    > 98%
  • CAS Number

    76-66-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Ho TY  et al. Uncaria rhynchophylla and rhynchophylline improved kainic acid-induced epileptic seizures via IL-1ß and brain-derived neurotrophic factor. Phytomedicine 21:893-900 (2014). Read more (PubMed: 24636743) »
  • Hao HF  et al. Inhibitory effect of rhynchophylline on contraction of cerebral arterioles to endothelin 1: Role of rho kinase. J Ethnopharmacol : (2014). Read more (PubMed: 24814318) »
  • Kushida H  et al. Simultaneous quantitative analyses of indole and oxindole alkaloids of Uncaria Hook in rat plasma and brain after oral administration of the traditional Japanese medicine Yokukansan using high-performance liquid chromatography with tandem mass spectrometry. Biomed Chromatogr 27:1647-56 (2013). Read more (PubMed: 23813572) »

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