Overview

  • Product name

    RI 1, RAD51 inhibitor
  • Description

    RAD51 inhibitor
  • Biological description

    RAD51 inhibitor. Inhibits homologous recombination and formation of subnuclear RAD51 foci in cells following DNA damage. Antitumor agent. Active in vitro.
  • Purity

    > 99%
  • CAS Number

    415713-60-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione
  • Molecular weight

    361.61
  • Molecular formula

    C14H11Cl3N2O3
  • PubChem identifier

    1074953
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Clc1ccc(cc1Cl)N3C(=O)C(N2CCOCC2)=C(Cl)C3=O
  • Source

    Synthetic

References

This product has been referenced in:

  • Bee L  et al. The efficiency of homologous recombination and non-homologous end joining systems in repairing double-strand breaks during cell cycle progression. PLoS One 8:e69061 (2013). Read more (PubMed: 23874869) »
  • Budke B  et al. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Res 40:7347-57 (2012). Read more (PubMed: 22573178) »

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