Anti-Ribonuclease T2 antibody (ab140191)

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Western blot - Anti-Ribonuclease T2 antibody (ab140191)

    Key features and details

    • Rabbit polyclonal to Ribonuclease T2
    • Suitable for: WB
    • Reacts with: Mouse, Rat, Human
    • Isotype: IgG

    Overview

    • Product name

      Anti-Ribonuclease T2 antibody

    • Description

      Rabbit polyclonal to Ribonuclease T2

    • Host species

      Rabbit

    • Specificity

      ab140191 is predicted to not cross-react with other RNASE family members.

    • Tested applications

      Suitable for: WBmore details

    • Species reactivity

      Reacts with: Mouse, Rat, Human

    • Immunogen

      A 16 amino acid synthetic peptide derived from near the C terminus of Human Ribonuclease T2.

    • Positive control

      • SW480 cell lysate

    • General notes

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    Applications

    Our Abpromise guarantee covers the use of ab140191 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    WB Use a concentration of 1 µg/ml. Predicted molecular weight: 29 kDa.

    Target

    • Tissue specificity

      Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain.

    • Involvement in disease

      Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly (LCWM) [MIM:612951]. An infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications.

    • Sequence similarities

      Belongs to the RNase T2 family.

    • Cellular localization

      Secreted. Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction.
    • Information by UniProt

    • Database links

      see all

    • Alternative names

      • bA514O12.3 antibody
      • Ribonuclease 6 antibody
      • Ribonuclease T2 antibody
      • RNASE6PL antibody
      • Rnaset2 antibody
      • RNT2_HUMAN antibody
      • RP11 514O12.3 antibody
      see all

    Images

    • Western blot - Anti-Ribonuclease T2 antibody (ab140191)
      Western blot - Anti-Ribonuclease T2 antibody (ab140191)
      All lanes : Anti-Ribonuclease T2 antibody (ab140191) at 1 µg/ml

      Lane 1 : SW480 cell lysate
      Lane 2 : SW480 cell lysate with blocking peptide

      Lysates/proteins at 15 µg per lane.

      Predicted band size: 29 kDa

    References (0)

    Publishing research using ab140191? Please let us know so that we can cite the reference in this datasheet.

    ab140191 has not yet been referenced specifically in any publications.

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