Anti-Ribonuclease T2 antibody (ab140191)
Key features and details
- Rabbit polyclonal to Ribonuclease T2
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Overview
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Product name
Anti-Ribonuclease T2 antibody -
Description
Rabbit polyclonal to Ribonuclease T2 -
Host species
Rabbit -
Specificity
ab140191 is predicted to not cross-react with other RNASE family members. -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
A 16 amino acid synthetic peptide derived from near the C terminus of Human Ribonuclease T2.
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Positive control
- SW480 cell lysate
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General notes
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
Our Abpromise guarantee covers the use of ab140191 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | Use a concentration of 1 µg/ml. Predicted molecular weight: 29 kDa. |
Target
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Tissue specificity
Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain. -
Involvement in disease
Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly (LCWM) [MIM:612951]. An infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications. -
Sequence similarities
Belongs to the RNase T2 family. -
Cellular localization
Secreted. Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction. - Information by UniProt
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Database links
- Entrez Gene: 8635 Human
- Entrez Gene: 100037283 Mouse
- Entrez Gene: 68195 Mouse
- Entrez Gene: 292306 Rat
- Omim: 612944 Human
- SwissProt: O00584 Human
- SwissProt: Q9CQ01 Mouse
- Unigene: 529989 Human
see all -
Alternative names
- bA514O12.3 antibody
- Ribonuclease 6 antibody
- Ribonuclease T2 antibody
see all
Images
Datasheets and documents
References (0)
ab140191 has not yet been referenced specifically in any publications.