Anti-Ribonuclease T2 antibody (ab140191)
- Datasheet
- References
- Protocols
Overview
-
Product name
Anti-Ribonuclease T2 antibody
See all Ribonuclease T2 primary antibodies -
Description
Rabbit polyclonal to Ribonuclease T2 -
Host species
Rabbit -
Specificity
ab140191 is predicted to not cross-react with other RNASE family members. -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
A 16 amino acid synthetic peptide derived from near the C terminus of Human Ribonuclease T2.
-
Positive control
- SW480 cell lysate
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
Applications
Our Abpromise guarantee covers the use of ab140191 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | Use a concentration of 1 µg/ml. Predicted molecular weight: 29 kDa. |
Target
-
Tissue specificity
Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain. -
Involvement in disease
Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly (LCWM) [MIM:612951]. An infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications. -
Sequence similarities
Belongs to the RNase T2 family. -
Cellular localization
Secreted. Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction. - Information by UniProt
-
Database links
- Entrez Gene: 8635 Human
- Entrez Gene: 100037283 Mouse
- Entrez Gene: 68195 Mouse
- Entrez Gene: 292306 Rat
- Omim: 612944 Human
- SwissProt: O00584 Human
- SwissProt: Q9CQ01 Mouse
- Unigene: 529989 Human
see all -
Alternative names
- bA514O12.3 antibody
- Ribonuclease 6 antibody
- Ribonuclease T2 antibody
see all
Images
-
Western blot - Anti-Ribonuclease T2 antibody (ab140191)All lanes : Anti-Ribonuclease T2 antibody (ab140191) at 1 µg/ml
Lane 1 : SW480 cell lysate
Lane 2 : SW480 cell lysate with blocking peptide
Lysates/proteins at 15 µg per lane.
Predicted band size: 29 kDa
Protocols
Datasheets and documents
References
ab140191 has not yet been referenced specifically in any publications.
