Ribostamycin sulfate, Antimicrobial  (ab145826)

Overview

  • Product name

    Ribostamycin sulfate, Antimicrobial 
  • Description

    Broad-spectrum antimicrobial originally isolated from Streptomyces ribosifidicus
  • Alternative names

    • Riboflavinesulfate
    • Ribomycine
    • Ribostamin
    • Vistamycin
  • Biological description

    Aminoglycoside antibiotic. Targets gram-positive and gram-negative bacteria. Inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding. Inhibits the chaperone activity of protein disulfide isomerase (PDI) but it does not inhibit the isomerase activity.

  • Purity

    > 95%
  • CAS Number

    53797-35-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S,3R,4S,5S,6S)-5-Amino-2-(aminomethyl)-6-[(1S,2S,3R,4S,6R)-4,6-diamino-2-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol sulfate
  • Molecular weight

    552.55
  • Molecular formula

    C17H34N4O10.H2O4S
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Horibe T  et al. Ribostamycin inhibits the chaperone activity of protein disulfide isomerase. Biochem Biophys Res Commun 289:967-72 (2001). Read more (PubMed: 11741285) »
  • Inouye S  et al. Comparative antimicrobial activities of ribostamycin, gentamicin, ampicillin and lincomycin in vitro and in vivo. Drugs Exp Clin Res 15:465-76 (1989). Read more (PubMed: 2632215) »
  • Kitasato I  et al. Comparative nephrotoxicity of ribostamycin and gentamicin in rats evaluated by urinalysis. Drugs Exp Clin Res 15:273-89 (1989). Read more (PubMed: 2591299) »

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