Product nameRibostamycin sulfate, Antimicrobial
DescriptionBroad-spectrum antimicrobial originally isolated from Streptomyces ribosifidicus
Aminoglycoside antibiotic. Targets gram-positive and gram-negative bacteria. Inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding. Inhibits the chaperone activity of protein disulfide isomerase (PDI) but it does not inhibit the isomerase activity.
Chemical name(2S,3R,4S,5S,6S)-5-Amino-2-(aminomethyl)-6-[(1S,2S,3R,4S,6R)-4,6-diamino-2-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol sulfate
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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This product has been referenced in:
- Horibe T et al. Ribostamycin inhibits the chaperone activity of protein disulfide isomerase. Biochem Biophys Res Commun 289:967-72 (2001). Read more (PubMed: 11741285) »
- Inouye S et al. Comparative antimicrobial activities of ribostamycin, gentamicin, ampicillin and lincomycin in vitro and in vivo. Drugs Exp Clin Res 15:465-76 (1989). Read more (PubMed: 2632215) »
- Kitasato I et al. Comparative nephrotoxicity of ribostamycin and gentamicin in rats evaluated by urinalysis. Drugs Exp Clin Res 15:273-89 (1989). Read more (PubMed: 2591299) »