Rifapentine (Priftin), RNA polymerase inhibitor (ab143073)

Overview

  • Product name

    Rifapentine (Priftin), RNA polymerase inhibitor
  • Description

    Mycobacterial DNA-dependent RNA polymerase inhibitor
  • Alternative names

    • Priftin
  • Biological description

    Mycobacterial DNA-dependent RNA polymerase inhibitor. Orally active. Antibacterial and antiparasitic agent. Active in vivo and in vitro.
  • CAS Number

    61379-65-5
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    877.03
  • Molecular formula

    C47H64N4O12
  • PubChem identifier

    45357190
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1C=CC=C(C(=O)NC2=C(C3=C(C(=C4C(=C3C(=O)C2=CNN5CCN(CC5)C6CCCC6)C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Almeida D  et al. Activities of rifampin, Rifapentine and clarithromycin alone and in combination against mycobacterium ulcerans disease in mice. PLoS Negl Trop Dis 5:e933 (2011). Read more (PubMed: 21245920) »
  • Araujo FG  et al. Rifapentine is active in vitro and in vivo against Toxoplasma gondii. Antimicrob Agents Chemother 40:1335-7 (1996). Read more (PubMed: 8725996) »
  • Yee YC  et al. A mechanism of rifamycin inhibition and resistance in Pseudomonas aeruginosa. J Antimicrob Chemother 38:133-7 (1996). Read more (PubMed: 8858465) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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