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    rilp-antibody-ab140188.pdf

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Immunology Adaptive Immunity T Cells Cytotoxic Cells
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Anti-RILP antibody (ab140188)

  • Datasheet
  • SDS
Submit a review Submit a question References (1)

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Western blot - Anti-RILP antibody (ab140188)
  • Immunocytochemistry/ Immunofluorescence - Anti-RILP antibody (ab140188)
  • Immunocytochemistry - Anti-RILP antibody (ab140188)

Key features and details

  • Rabbit polyclonal to RILP
  • Suitable for: ICC/IF, WB, ICC
  • Reacts with: Mouse, Human
  • Isotype: IgG

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Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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Overview

  • Product name

    Anti-RILP antibody
  • Description

    Rabbit polyclonal to RILP
  • Host species

    Rabbit
  • Specificity

    At least two isoforms of RILP are known to exist; ab140188 will only detect the longer isoform.
  • Tested applications

    Suitable for: ICC/IF, WB, ICCmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    An 18 amino acid synthetic peptide near the center of Human RILP.

  • Positive control

    • A20 cell lysate; HeLa cells
  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer

    pH: 7.2
    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Immunology
    • Adaptive Immunity
    • T Cells
    • Cytotoxic Cells
    • Tags & Cell Markers
    • Subcellular Markers
    • Organelles
    • Endosome
    • Tags & Cell Markers
    • Subcellular Markers
    • Organelles
    • Lysosome
    • Signal Transduction
    • Protein Trafficking
    • Vesicle Transport
    • Regulation

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • A20 whole cell lysate (ab7180)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab140188 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF
Use a concentration of 20 µg/ml.
WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 44 kDa.
ICC
Use a concentration of 2.5 µg/ml.
Notes
ICC/IF
Use a concentration of 20 µg/ml.
WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 44 kDa.
ICC
Use a concentration of 2.5 µg/ml.

Target

  • Function

    Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes.
  • Tissue specificity

    Ubiquitous. Strongly expressed in fetal heart, heart, stomach, spleen, adrenal gland, thyroid gland, salivary gland, fetal liver, liver and lung. Poorly expressed in brain.
  • Sequence similarities

    Contains 1 RILP-like domain.
  • Cellular localization

    Endomembrane system. Late endosome membrane. Lysosome membrane. Cytoplasmic vesicle > phagosome membrane. Associated with late endosomal, lysosomal and phagosomal membranes. The interaction with RAB7A is necessary for its recruitment to phagosomes.
  • Target information above from: UniProt accession Q96NA2 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 83547 Human
    • Entrez Gene: 280408 Mouse
    • Omim: 607848 Human
    • SwissProt: Q96NA2 Human
    • SwissProt: Q5ND29 Mouse
    • Unigene: 534497 Human
    • Unigene: 41416 Mouse
    • Alternative names

      • FLJ31193 antibody
      • PP10141 antibody
      • Rab interacting lysosomal protein antibody
      • Rab-interacting lysosomal protein antibody
      • Rilp antibody
      • RILP_HUMAN antibody
      see all

    Images

    • Western blot - Anti-RILP antibody (ab140188)
      Western blot - Anti-RILP antibody (ab140188)
      All lanes : Anti-RILP antibody (ab140188) at 1 µg/ml

      Lane 1 : A20 cell lysate
      Lane 2 : A20 cell lysate with blocking peptide

      Lysates/proteins at 15 µg per lane.

      Predicted band size: 44 kDa

    • Immunocytochemistry/ Immunofluorescence - Anti-RILP antibody (ab140188)
      Immunocytochemistry/ Immunofluorescence - Anti-RILP antibody (ab140188)
      Immunofluorescence of RILP in HeLa cells with ab140188 at 20 ug/mL.
    • Immunocytochemistry - Anti-RILP antibody (ab140188)
      Immunocytochemistry - Anti-RILP antibody (ab140188)
      Immunocytochemical analysis of HeLa cells labelling RILP with ab140188 at 2.5 µg/ml.

    Protocols

    • Western blot protocols
    • Immunocytochemistry & immunofluorescence protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (1)

    Publishing research using ab140188? Please let us know so that we can cite the reference in this datasheet.

    ab140188 has been referenced in 1 publication.

    • Zhao Y  et al. Dihydroartemisinin Ameliorates Learning and Memory in Alzheimer's Disease Through Promoting Autophagosome-Lysosome Fusion and Autolysosomal Degradation for Aß Clearance. Front Aging Neurosci 12:47 (2020). PubMed: 32210783

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