Overview

  • Product name

  • Description

    Rabbit polyclonal to RILP
  • Host species

    Rabbit
  • Specificity

    At least two isoforms of RILP are known to exist; ab140188 will only detect the longer isoform.
  • Tested applications

    Suitable for: ICC/IF, WB, ICCmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    An 18 amino acid synthetic peptide near the center of Human RILP.

  • Positive control

    • A20 cell lysate; HeLa cells

Properties

Applications

Our Abpromise guarantee covers the use of ab140188 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 44 kDa.
ICC Use a concentration of 2.5 µg/ml.

Target

  • Function

    Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes.
  • Tissue specificity

    Ubiquitous. Strongly expressed in fetal heart, heart, stomach, spleen, adrenal gland, thyroid gland, salivary gland, fetal liver, liver and lung. Poorly expressed in brain.
  • Sequence similarities

    Contains 1 RILP-like domain.
  • Cellular localization

    Endomembrane system. Late endosome membrane. Lysosome membrane. Cytoplasmic vesicle > phagosome membrane. Associated with late endosomal, lysosomal and phagosomal membranes. The interaction with RAB7A is necessary for its recruitment to phagosomes.
  • Information by UniProt
  • Database links

  • Alternative names

    • FLJ31193 antibody
    • PP10141 antibody
    • Rab interacting lysosomal protein antibody
    • Rab-interacting lysosomal protein antibody
    • Rilp antibody
    • RILP_HUMAN antibody
    see all

Images

  • All lanes : Anti-RILP antibody (ab140188) at 1 µg/ml

    Lane 1 : A20 cell lysate
    Lane 2 : A20 cell lysate with blocking peptide

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 44 kDa

  • Immunofluorescence of RILP in HeLa cells with ab140188 at 20 ug/mL.
  • Immunocytochemical analysis of HeLa cells labelling RILP with ab140188 at 2.5 µg/ml.

References

ab140188 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab140188.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up