Overview

  • Product name
  • Description
    Rabbit polyclonal to RILP
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human RILP (internal sequence). The exact sequence is proprietary. Consists of 18 amino acids.
    Database link: Q96NA2

  • Positive control
    • Human adrenal tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab174737 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 44 kDa.

Target

  • Function
    Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes.
  • Tissue specificity
    Ubiquitous. Strongly expressed in fetal heart, heart, stomach, spleen, adrenal gland, thyroid gland, salivary gland, fetal liver, liver and lung. Poorly expressed in brain.
  • Sequence similarities
    Contains 1 RILP-like domain.
  • Cellular localization
    Endomembrane system. Late endosome membrane. Lysosome membrane. Cytoplasmic vesicle > phagosome membrane. Associated with late endosomal, lysosomal and phagosomal membranes. The interaction with RAB7A is necessary for its recruitment to phagosomes.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ31193 antibody
    • PP10141 antibody
    • Rab interacting lysosomal protein antibody
    • Rab-interacting lysosomal protein antibody
    • Rilp antibody
    • RILP_HUMAN antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed, paraffin embedded sections of Human adrenal tissue  labeling RILP with ab174737 at  5 µg/ml.

References

ab174737 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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