Riluzole (PK 26124), GABA uptake inhibitor (ab120272)
Key features and details
- Neuroprotective agent. Modulates glutamate transmission.
- CAS Number: 850608-87-6
- Soluble in DMSO to 100 mM and in water to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Riluzole (PK 26124), GABA uptake inhibitor -
Description
Neuroprotective agent. Modulates glutamate transmission. -
Alternative names
- EAA2_HUMAN
- EAAT2
- Excitatory amino acid transporter 2
see all -
Biological description
Neuroprotective agent with anticonvulsant, sedative, anxiolytic, anti-ischemic and anesthetic properties. Inhibits glutamate release, enhances glutamate uptake, blocks voltage-dependent Na+ channels, antagonises NMDA receptors and inhibits GABA uptake. Reported to offer neuroprotection and some therapeutic potential for amyotrophic lateral sclerosis and Huntingdon's disease.
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CAS Number
850608-87-6 -
Chemical structure
Properties
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Chemical name
2-Amino-6-trifluoromethoxybenzothiazole hydrochloride -
Molecular weight
270.66 -
Molecular formula
C8H5F3N2OS.HCl -
PubChem identifier
6419992 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in water to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.FC(F)(F)Oc1ccc2nc(N)sc2c1 -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (3)
ab120272 has been referenced in 3 publications.
- Wei XP et al. A novel reticular node in the brainstem synchronizes neonatal mouse crying with breathing. Neuron 110:644-657.e6 (2022). PubMed: 34998469
- Mishra P & Narayanan R Conjunctive changes in multiple ion channels mediate activity-dependent intrinsic plasticity in hippocampal granule cells. iScience 25:103922 (2022). PubMed: 35252816
- Ramakrishnan L et al. Riluzole attenuates the effects of chemoconvulsants acting on glutamatergic and GABAergic neurotransmission in the planarian Dugesia tigrina. Eur J Pharmacol 718:493-501 (2013). PubMed: 23872399