Rimantadine hydrochloride, M2 proton channel inhibitor (ab143448)

Overview

  • Product name

    Rimantadine hydrochloride, M2 proton channel inhibitor
  • Description

    M2 proton channel inhibitor
  • Biological description

    M2 proton channel inhibitor. Inhibits influenza A virus in vivo. Shows greater blood-brain barrier permeability than amantadine hydrochloride (ab142477). Orally active.
  • Purity

    > 98%
  • CAS Number

    1501-84-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-(1-Adamantyl)ethanamine hydrochloride
  • Molecular weight

    215.76
  • Molecular formula

    C12H21N.HCl
  • PubChem identifier

    15165
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C12CC3CC(C1)CC(C3)C2)N.C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Won JN  et al. Antiviral activity of the plant extracts from Thuja orientalis, Aster spathulifolius, and Pinus thunbergii against influenza virus A/PR/8/34. J Microbiol Biotechnol 23:125-30 (2013). Read more (PubMed: 23314378) »
  • Balgi AD  et al. Inhibitors of the influenza A virus M2 proton channel discovered using a high-throughput yeast growth restoration assay. PLoS One 8:e55271 (2013). Read more (PubMed: 23383318) »
  • Kooijmans SA  et al. The involvement of a Na?- and Cl?-dependent transporter in the brain uptake of amantadine and rimantadine. Mol Pharm 9:883-93 (2012). Read more (PubMed: 22352408) »
  • Smee DF  et al. Treatment of oseltamivir-resistant influenza A (H1N1) virus infections in mice with antiviral agents. Antiviral Res 96:13-20 (2012). Read more (PubMed: 22809862) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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