Rimonabant, cannabinoid CB1 receptor antagonist/inverse agonist (ab144582)

Overview

  • Product name

    Rimonabant, cannabinoid CB1 receptor antagonist/inverse agonist
  • Description

    Potent and selective cannabinoid CB1 receptor antagonist/inverse agonist
  • Biological description

    Potent and selective cannabinoid CB1 receptor antagonist/inverse agonist (Ki = 2 nM). Shows anoretic, antiobesogenic and central psychoactive effects in vivo. Blood-brain barrier permeable. Orally active.
  • Purity

    > 98%
  • CAS Number

    168273-06-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidin-1-yl-1H-pyrazole-3-carboxamide
  • Molecular weight

    463.80
  • Molecular formula

    C22H21Cl3N4O
  • PubChem identifier

    104850
  • Storage instructions

    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Buckley JL & Rasmussen EB Rimonabant's reductive effects on high densities of food reinforcement, but not palatability, in lean and obese Zucker rats. Psychopharmacology (Berl) : (2014). Read more (PubMed: 24398820) »
  • Blanco-Calvo E  et al. Pharmacological blockade of either cannabinoid CB1 or CB2 receptors prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rat. Front Integr Neurosci 7:106 (2014). Read more (PubMed: 24409127) »
  • Oliviero A  et al. CB1 receptor antagonism/inverse agonism increases motor system excitability in humans. Eur Neuropsychopharmacol 22:27-35 (2012). Read more (PubMed: 21571507) »
See all 2 Publications for this product

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