Anti-RIN1 antibody (ab138097)
Key features and details
- Rabbit polyclonal to RIN1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-RIN1 antibody
See all RIN1 primary antibodies -
Description
Rabbit polyclonal to RIN1 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide derived from the C terminal of Human RIN1.
-
Positive control
- COLO205 cell lysate.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20ºC. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
PBS is without Mg2+ and Ca2+ -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Purification notes
ab138097 was affinity-purified from rabbit antiserum by immunogenic peptide affinity-chromatography. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab138097 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/500 - 1/1000. Predicted molecular weight: 84 kDa.
|
Notes |
---|
WB
1/500 - 1/1000. Predicted molecular weight: 84 kDa. |
Target
-
Relevance
RIN1 is a Ras effector protein which can affect Ras signaling in a variety of ways. It enhances signaling from ABL1 and ABL2 whcih are involved in regulation of cytoskeletal remodeling. It may function as a guanine nucleotide exchange factor in activation of Rab5a. Rin1 also competes with RAF1 for binding of the activated form of Ras. It may play a role inhibiting the modulation of neuronal plasticity in formation of aversive memory, and has been implicated as a tumor supressor gene in breast cancer. -
Cellular localization
Cytoplasmic and Plasma membrane -
Database links
- Entrez Gene: 9610 Human
- Entrez Gene: 225870 Mouse
- Entrez Gene: 207119 Rat
- Omim: 605965 Human
- SwissProt: Q13671 Human
- SwissProt: Q921Q7 Mouse
- SwissProt: P97680 Rat
-
Alternative names
- Ras and Rab interactor 1 antibody
- ras inhibitor 1 antibody
- ras inhibitor antibody
see all
Images
Datasheets and documents
-
SDS download
-
Datasheet download
References (0)
ab138097 has not yet been referenced specifically in any publications.