Overview

  • Product name

    Anti-RIN1 antibody - C-terminal
    See all RIN1 primary antibodies
  • Description

    Rabbit polyclonal to RIN1 - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human RIN1 (C terminal). The exact sequence is proprietary.
    Database link: Q13671

  • Positive control

    • WB: HEK-293T, HeLa and HepG2 whole cell extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab229684 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 84 kDa.

Target

  • Relevance

    RIN1 is a Ras effector protein which can affect Ras signaling in a variety of ways. It enhances signaling from ABL1 and ABL2 whcih are involved in regulation of cytoskeletal remodeling. It may function as a guanine nucleotide exchange factor in activation of Rab5a. Rin1 also competes with RAF1 for binding of the activated form of Ras. It may play a role inhibiting the modulation of neuronal plasticity in formation of aversive memory, and has been implicated as a tumor supressor gene in breast cancer.
  • Cellular localization

    Cytoplasmic and Plasma membrane
  • Database links

  • Alternative names

    • Ras and Rab interactor 1 antibody
    • ras inhibitor 1 antibody
    • ras inhibitor antibody
    • Ras inhibitor JC99 antibody
    • ras inhibitor RIN1 antibody
    • Ras interaction/interference protein 1 antibody
    • RIN 1 antibody
    see all

Images

  • All lanes : Anti-RIN1 antibody - C-terminal (ab229684) at 1/1000 dilution

    Lane 1 : HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell extract
    Lane 2 : HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell extract
    Lane 3 : HepG2 (human liver hepatocellular carcinoma cell line) whole cell extract

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 84 kDa



    7.5% SDS-PAGE gel.

References

ab229684 has not yet been referenced specifically in any publications.

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