Overview

  • Product name

    RITA, p53 activator
  • Description

    p53 activator
  • Alternative names

    • 2,5-bis(5-hydroxymethyl-2-thienyl) Furan
    • NSC 652287
    • p53 Activator III
    • Reactivation of p53 and induction of tumor cell apoptosis
  • Biological description

    p53 activator. Tricyclic thiophene derivative that binds to p53 and induces its accumulation in tumor cells. Prevents p53-HDM2 (MDM2) interaction in vitro and in vivo and affects p53 interaction with several negative regulators. Induces expression of p53 target genes and apoptosis in various tumor cell lines expressing wild-type p53.

  • Purity

    > 98%
  • CAS Number

    213261-59-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol
  • Molecular weight

    292.37
  • Molecular formula

    C14H12O3S2
  • PubChem identifier

    374536
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=C(SC(=C1)C2=CC=C(O2)C3=CC=C(S3)CO)CO
  • Source

    Synthetic

References

This product has been referenced in:

  • Zhao CY  et al. Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation. Cancer Res 70:3372-81 (2010). Read more (PubMed: 20395210) »
  • Issaeva N  et al. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat Med 10:1321-8 (2004). Read more (PubMed: 15558054) »
  • Rivera MI  et al. Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism. Biochem Pharmacol 57:1283-95 (1999). Read more (PubMed: 10230772) »
  • Nieves-Neira W  et al. DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells. Mol Pharmacol 56:478-84 (1999). Read more (PubMed: 10462535) »

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