Key features and details
- p53 activator
- CAS Number: 213261-59-7
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Product nameRITA, p53 activator
- 2,5-bis(5-hydroxymethyl-2-thienyl) Furan
- NSC 652287
- p53 Activator III
- Reactivation of p53 and induction of tumor cell apoptosis
p53 activator. Tricyclic thiophene derivative that binds to p53 and induces its accumulation in tumor cells. Prevents p53-HDM2 (MDM2) interaction in vitro and in vivo and affects p53 interaction with several negative regulators. Induces expression of p53 target genes and apoptosis in various tumor cell lines expressing wild-type p53.
This product is manufactured by BioVision, an Abcam company and was previously called 2469 RITA. 2469-25 is the same size as the 25 mg size of ab219379.
Storage instructionsShipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Vitamin D Receptor
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab219379 has not yet been referenced specifically in any publications.